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7 Cards in this Set
- Front
- Back
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Which disease has the swiss cheese configuration?
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Simple endometrial hyperplasia (cystic and mild)
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What is the most common gyn cancer in USA?
What are some characteristics of the cancer? |
endometrial adenoca
mostly peri- and post-menopausal highly estrogen dependent assoc. with PTEN and p53 Increased risk with hormone replacement, and Tamoxifen RISK TRIAD of obesity, diabetes, and hypertension |
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What are characteristics of Lynch syndrome (HNPCC or Hereditary nonpolyposis colorectal cancer)?
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younger ages
lymphocytic infiltrate microsatellite instability, and mismatch repair mutation |
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What are the steps to Type II endometroid carcinoma? (simpler progression than type I)
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atrophic endometrium to intraepithelial carcinoma (via p53 mutation) to serous carcinoma.
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What is an adenoacanthoma?
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adenocarcinoma in which some of the cells exhibit squamous differentiation.
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Good prognosis?
Type? Age? Risk factor? Hormone dependency? First step? Mutations? Treatment? |
Adenocanthoma
Perimenopausal age Obesity and diabetes Hormone dependent Preceded by hyperplasia PTEN and microsatellite mutations Can treat with estrogen |
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Poor prognosis:
Type? Age? Hormone dependency? Risk factors? First step? Mutations? |
Serous papillary and clear cell
Late menopause Hormone receptor negative No prior risk factors Began at high grade p53 mutation |
