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5 Cards in this Set

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-below what BG do Sx of hypoglycemia occur?
-when does impaired cognitive fxn occur (cna't concentration, hard to speak, blurred vision)
-Sx of hypoglycemia when BG<55
-impaired cognitive fxn when BG<50
def of hypoglycemia
*after 8-10 hr of overnight fast:
-plasma glucose<60
-blood glucose<50

*anytime:
-plasma glucose<50
-blood glucose<40
***Whipple's triad of clinically-significant hypoglycemia
1. Sx with simultaneous documentation of
2. *biochemical hypoglycemia that
3. improve or disappear following ingestion of carbs

*Biochemical hypoglycemia:
--AFter 8-10 h overnight fast:
~plasma glucose<60
~blood glucose<50

--Anytime
~plasma glucose<50
-blood glucose <40
drugs that cause hypoglycemia
MCC=insulin
2nd MCC=sulfonylureas (glipizide, gliburide, glimepiride)
nl vs abnl response to OGTT
OGTT=75 grams of oral glucose

nl response: peak glucose and insulin are both 1 hr after intake

abnl: insulin peak is 2 hrs after (thus, not soon enough, BG already high)