Endo

Front 1

Pituitary located in

Back 1

Sella turcica

Front 2

Hypothalamic hormone reach ant pit by

Back 2

Hypothalamic hypophyseal portal system

Front 3

Hypothalamic hormone reach post pit by

Back 3

Neurosecretory fibers in connecting stalk

Front 4

Ghrh and somatostatin released by

Back 4

Hypothalamus

Front 5

Synthetic prep of ghrh is

Back 5

sermorelin

Front 6

Somatostatin produced by

Back 6

Hypothalamus pancreas and gastroduodenal mucosa

Front 7

Stimuli for GH release

Back 7

Ghrh insulin sleep exercise

Front 8

Somatostatin also inhibit the release of

Back 8

Tsh, insulin and glucagon.

Gastrin, VIP, gastric acid.

Front 9

Octreotide

Back 9

Somatostatin analogue

Front 10

Advantages of octreotide

Back 10

No rebound hypersecrrtion after stopping the drug.

Longer half life

Front 11

Uses of octreotide

Back 11

Tx of carcinoids, vipomas

Tx of diarrhea

Variceal bleeding

Gigantism acromegaly

Front 12

Side effects of octreotide

Back 12

Steatorrhea nv cramps

Front 13

GH has

Back 13

191 aminoacids

Front 14

GH secretion

Back 14

Secreted in 0.5 mg per day in 6-8 separate bursts.

Front 15

Most pronounced secretion of GH occurs after

Back 15

Deep sleep

Front 16

Dopamine serotonin and alpha agonists effect on GH

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Stimulate

Front 17

Beta agonists igf1 and free fatty acids

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Decrease GH release

Front 18

GH has direct effects on

Back 18

Lipid and carb metabolism

Front 19

Anabolic effect of GH are mediated by

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Igf 1

Front 20

Igf2 has

Back 20

Insulin like effects

Front 21

Growth hormone causes growth of every organ except

Back 21

Brain and eye

Front 22

Sensitive index of GH action

Back 22

Growth of thymus

Front 23

Growth hormone inc size/number of cells

Back 23

Number

Front 24

Growth hormone switches the feul of body from

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Carbohydrate to fat

Front 25

Growth also affected by

Back 25

Thyroid, insulin, androgens, glucocorticoids

Front 26

Congenital GH def

Back 26

Craniopharyngioma, ghrh deficiency

Front 27

Acquired deficiency of gh

Back 27

Removal of pituitary by surgery

Front 28

GH deficiency criteria

Back 28

Growth rate below 4 cm per yr

Abs of GH response to provocative tests

Low conc of igf 1

Front 29

Therapy of GH duration

Back 29

8-12 months. Tx with sex hormone at puberty

Front 30

Route of GH

Back 30

Im or subcu injection,

Front 31

T half of gh

Back 31

20-30 min

Front 32

Normal plasma conc of GH is <3ng per ml reach within

Back 32

2-6 hrs

Front 33

Igf appear after injection of GH after

Back 33

20 hrs

Front 34

GH adverse effects

Back 34

Pain at site of injection

Lipoatrophy

Antibody formation

Front 35

Contraindication of gh

Back 35

Pt with closed epiphyses

Expanding intracranial tumors

Front 36

Oxytocin realesd by sensory stimuli arising from

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cervix vagina and breast

Front 37

Effects of oxytocin

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Labour

Milk ejection

Constrict umbilical arteries

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Route of oxytocin

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Iv

Front 39

T half of oxytocin

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5min

Front 40

Side effects of oxytocin

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Rupture of uterus

Hypotension or fluid retention

Fetal asphyxia and arryrhmia

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Contra indication

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Fetal distress

Pre maturity

Abnormal fetal presentation

Cephalopelvic disproportion

Front 42

Fear anxiety pain effect on oxytocin

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Decrease

Front 43

Alcohol effect

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Dec oxytocin

Front 44

Estrogen oxytocin

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Increase uterine sensitivity

Front 45

Progesterone

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Dec uterine sensitivity

Front 46

Vasopressin effects

Back 46

V1 vasoconstriction

V2 antidiuretic in kidney

V2 release of vWF and factor 8 in bvs

Front 47

Inactivation of adh by

Back 47

Vasopressinase

Front 48

Uses of vasopressin

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Di

Variceal and diverticular bleeding

Vwdisease

Hemophilia

Front 49

Sideeffecya of adh

Back 49

Hyponatremia and water intoxication

Pallor headache nausea abd cramps allergic reaction

Ci in cad

Front 50

Back 50

Drug interactions

Front 51

Siadh tx

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Lithium and demelocycline

Front 52

Side effects of lithium

Back 52

Tremors nv leukocutosis vertigo RTA polyuria inc thirst and severe hypernatremia