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40 Cards in this Set
- Front
- Back
Lower Respiratory system develops?
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Develops as an out pocketing from cranial foregut, beginning 4th week
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Lower Respiratory system contains?
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Larynx, Trachea, Bronchi, Lungs
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Respiratory Primordium begins as?
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Laryngotracheal diverticulum
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Laryngotracheal diverticulum lined by?
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Endoderm---forms epithelium and glands of lower respiratory tract
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Location of laryngotracheal diverticulum?
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Between 4th and 6th pharyngeal arch
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Which pharyngeal arch does not develop?
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5th
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4th and 6th pharyngeal arch innervated by?
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Vagus nerve
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Tracheoesophageal folds
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Layer of splanchnic mesoderm that closes off laryngotracheal diverticulum to separate respiratory and digestive systems
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Tracheoesophageal fistulas
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Result of trachea and esophagus not being closed off properly; somehow connected
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VACTERL
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Anomalies associated with Tracheoesophageal atresia
Vertebral anomalies Anal atresia Cardiovascular anomalies Tracheoesophageal fistula Esophageal atresia Renal and/or radial anomalies Limb anomalies |
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Development of bronchi and lungs
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Successive branching off of diverticulum
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Visceral pleura
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Derived from splanchnic mesoderm
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Parietal pleura
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Derived from somatic mesoderm
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Primary bronchus
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Formed Week 5; Right subdivides into 3 secondary bronchi and left subdivides into 2 secondary bronchi
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Before birth, lungs full of?
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Fluid
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Fetuses born at less than 20 weeks gestation
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Rarely survive because respiratory system not sufficiently mature
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Fetuses born between 25-28 weeks gestation
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Can survive with intensive care; earliest period at which fetuses can survive
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Lungs mature at birth?
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No. Over 95% of alveoli formed after birth.
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Respiratory Distress Syndrome
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Deficiency or absence of surfactant
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Surfactant
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Allows alveoli to expand with less inflation pressure
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Thyroxine and cortisol
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Help to increase production of surfactant
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Hyaline membrane disease
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Collapsed alveoli that resemble a glass membrane
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Right atrium develops from?
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Right horn of sinus venous, called sinus venarum; primitive atrium forms auricle
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Primitive atrium forms?
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Right and left auricle
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Left atrium develops from?
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Incorporation of primitive pulmonary vein and its branches; primitive atrium forms auricle
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Truncal and bulbar ridges are populated with?
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Neural crest cells
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Aorticopulmonary septum development
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Swellings in wall of truncus arteriosus (truncal ridges) and bulbis cords (bulbar ridges); formed as spiral
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Aorta path in aorticopulmonary septum
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Behind septum and then spiral to front
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Pulmonary trunk path in aorticopulmonary septum
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In front of septum then spiral to back
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Persistant Truncus Arteriosus
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Abnormal neural crest cell migration; only partial development of AP septum; only a large vessel leaves heart, receiving blood from both ventricles
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Sign of persistent truncus arteriosus
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Cyanosis
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Transposition of Great Arteries
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Most common cause of cyanotic heart disease in newborns; AP septum grows in straight line instead of spiral; Aorta and pulmonary trunk associated with wrong ventricle
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Tetralogy of Fallot
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Abnormal neural crest cell migration; truncus arterioles not divided equally; results in pulmonary stenosis and overriding aorta and ultimately VSD (ventricular septal defect); marked cyanosis
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4 classic malformations of Tetralogy of Fallot
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1. Pulmonary stenosis
2. Right ventricular hypertrophy 3. Overriding aorta 4. Ventricular septal defect |
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Ventricular septal defects (VSD)
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Most common type of cardiac defect; Abnormal opening in wall between two ventricles
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3 forms of VSD
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Membranous VSD
Muscular VSD Common ventricle |
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Membranous VSD
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Most common; Failure of membranous part of interventricular septum to develop results in patent interventricular foramen; Lack of fusion of bulbar ridges and endocardial cushions
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Muscular VSD
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Excessive cavitation in muscular septum
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Common ventricle
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Interventricular septum fails to form completely resulting in 3 chambered heart
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Endocardial Cushion defect
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Cushions fail to fuse to make cross, resulting in persistent atrioventricular canal
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