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14 Cards in this Set

  • Front
  • Back
DSIF function
Inhibits elongation
CTD truncation of RNA polymerase results in what activity?
No progression of RNA pol
Elongator is what type of transcription factor?
Histone acetyl transferase
NELF function
Inhibits elongations by binding RNA
P-TEFb function and what is required for it to be active?
Function: to antagonize NELF and DSIF.
Cdk9 is required for its kinase activity
SII function
prevents arrest and promotes nascent transcript cleavage
suppresses pausing
N protein function (2 forms)
Non-processive: binds to box A and allows RNA processivity

Processive: associates with RNA and allows it to be processive throughout elongation and is site independent.
lambda Q function (2 models)
Site release and complexes with RNA polymerase
DNA folding
What factor is important for initiation?

Initiation: sigma factor determines which start codon is required

Termination is caused by a NusA factor.
Cdk9 activity is required for two things:
Activation of PTEFb

Tat dependent elongation
Represses RNA pol III transcription by binding to the TFIIIB portion
Phosphorylates TFIIIB subunit and stimulates the assembly of the complex
phosphorylates BRF1
stiumlates the assembly of the complex.