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19 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Maintains Patent Ductus Arteriosis
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Alprostadil (PGE1)
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IV infusion
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PGE1 derivative that is used for cytoprotection of NSAID induced peptic ulcers.
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Misoprostol
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PGE2 Derivative that stimulates uterine contractions. Also 96% effective in inducing abortions at 14-20 weeks gestation. Induction of term labor.
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Dinoprostone
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Vaginal Suppository. Also used to control postpartum hemorrhage.
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Tx for SEVERE Pulmonary Hypertension. PGI2 Derivative. In trials for tx of Raynaud's
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Iloprost
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Also causes decreased platelet hyperaggregation in peripheral vascular disease.
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Tx of PRIMARY Pulmonary hypertension. PGI2 derivative.
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Epoprostenol
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Also causes decreased platelet hyperaggregation in peripheral vascular disease.
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69% effective in aborting 14-20 week fetuses. Stimulates uterine contractions similar to those during term labor. PGF-2 alpha derivative
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Carboprost.
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Also used to control postpartum hemorrhave.
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Ophthalmic solution to reduce IOP. Activates FP receptors and increases outflow of aq hum.
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Latanoprost (PGF2 alpha analog)
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Can be used as a replacement for heparin in dialysis patients.
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PGI2
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inhibits 5-lipoxygenase. Reduces leukotriene biosynthesis. Inhibits a number of microsomal P-450 enzymes. Used to treat mild persistent asthma.
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Zileuton (Leukotriene Modifier)
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Antagonist of leukotriene LTD4 receptor. Used to treat mild persistent asthma as an alternative to inhaled glucocorticoids.
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Montekulast (Singulair)
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Leukotriene modifier
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Prostaglandins most important for pain.
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PGE2 and PGI2
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Irreversibly acetylates COX-1 and 2. Platelets can't make it so they can't clot. Zero order metabolism at high doses due to limited capacity of liver conjugation. Know SE's.
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Aspirin (ASA)
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SE: Ulceration, hepatotoxicity is dose dependent, Reye's syndrome (consequence of viral infection in young patient), Nephrotoxicity in extended use and acetaminophen. TOXIC EFFECTS: tinnitus is an early sign, precipitation of bronchoconstriction on asthmatics. ABSOLUTE CI: Asthma
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Most potent inhibitor of PGH synthase. Interferes with active site of COX1 and 2. Inhibition in NON-COVALENT, Competitive inhibition of arachidonate binding. Toxic effects seen in 35-50% of patients. Used to treat acute gout, acute flare up of chronic RA and is the drug of choice in ANKYLOSING SPONDYLOSIS.
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Indomethacin (Acetic Acid)
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Only NSAID that can be administered IV.
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Ketorolac
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Propionic acid used in RA for analgesia. Non-covalent inhibition of COS1 and 2, with no specificity for one or the other.
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Ibuprofen
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Propionic acid with a longer half life than ibuprofen.
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Naproxen (Aleve)
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Relatively specific inhibitor of COX2. Competitive inhibitor. Reduced gastroduodenal erosion. Approved for OA, RA and patients with history of ulcers.
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Celecoxib (Celebrex)
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Increase in MI and Stroke
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Most commonly used NSAID in Europe. 5-10 fold COX2 specificity.
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Diclofenac
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Analgesic, antipyretic with little antiinflammatory activity. Inhibition of prostaglandin biosynthesis, but has more of an effect in the CNS than in the periphery. Drug of choice in pregnant women. Reduced risk of peptic ulcers, fewer renal adverse effects and does not diminish platelet aggregation.
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Acetaminophen (Tylenol)
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