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22 Cards in this Set

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PGE 2
synthesized in Kidney, spleen, heart
causes vasodilation, enhancement of effects of bradykinin and histamine, inductin of uterine contractions, and platelet aggregation, maintaining the open passageway of the fetal ductus arteriosus
PGI 2
produced in heart, vascular endothelial cells
causes inhibition of platelet aggregation, induces vasodilation
TXA 2
produced by platelets
induces platelet aggregation and vascnstriction
LTC 4
produced by monocytes, basophils, neutrophils, eisinophils, mast cells, epithelial cells
Compnonent of SRS-A, induces vasodilation and bronchoconstriction
increases vascular permeability
LTD 4
produced by monocytes and alveolar macrophages, eisinophils, mast cells, epithelial cells
is the predominant component of SRS-A2, induces vasodilation and bronchoconstriction
increases vascular permeability
Omega 6 FA
found in fish, peanut oil, and as suppliment
Produces group 1 and 2 prostoglandins and leukotrienes
forms arachadonic acid
linoleate acid
Omega 3 FA
found in fish, peanut oil, and as a suppliment
forms group 3 prostanoids and leukotrienes
alpha linolenate
Arachadonic acid
produced by phospholipase A2 pathway, releases from phosphotidylcholine
in phospholipase C pathway, released from DAG and MAG by DAG and MAG lipase
can produce cyclooxygenase and lipoxygenases
produced from linoleate acid
Phospholipase A 2 pathway
produces arachodonic acid from phosphotidylcholine
Ca is cofactor
Phospholipase C pathway
produces arachodonic acid from DAG with DAG and MAG lipase
Arachodonic acid byproducts
5-lipoxygenase produces LTA4, LTE4, and LTB4
LTA 4
produced from arachadonic acid by 5-lipoxygenase
in leukocytes, platelets, mast cells, and heart and lung vascular tissues
as LTE4, causes bronchoconstriction, increased vasculature permeability, and components of slow reacting substance of anaphylaxis
as LTB4, causes increased chemotaxis of PMNs, release of lysosomal enzymes, and adhesion of WBCs
LTE 4
produced from LTA4, first LTC4, then LTD4causes bronchoconstriction, increased vasculature permeability, and components of slow reacting substance of anaphylaxis
LTB 4
produced from LTA4, causes increased chemotaxis of PMNs, release of lysosomal enzymes, and adhesion of WBCs
Aspirin
irreversibly inactivates COX-1 and COX-2
used for treatment of stroke
irreversibly inhibits production of TXA2 in platelets and PGI2 in endothelial vessels
COX 1
constitutive cyclooxygenase
prodces PGG2 from arachadonic acid
PGG2
produced from arachadonic acid by COX 1 and 2
GSH peroxidase produces PGH2, then TXA2, PGI2, PGF2, and PGE2
COX 2
non-constitutive enzyme
inhibited by apsirin corticosteroids, and selective inhibitors
induced by cytokines, endotoxin, growth factor, tumor promotors
TXA 2 production by paltelets
irreversibly inhibited by aspirin
leads to a decrease in platelet aggregation
PGI 2 production by endothelium cells
inhibited by aspirin
can remake
vasodilation and decreased platelet aggregation
lipoxygenase pathway
produces leukotrienes, lipoxin, and hydroperoxy from arachadonic acid
cyclooxygenase pathway
produces prostoglandins and thromboxane from arachadonic acid