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22 Cards in this Set
- Front
- Back
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PGE 2
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synthesized in Kidney, spleen, heart
causes vasodilation, enhancement of effects of bradykinin and histamine, inductin of uterine contractions, and platelet aggregation, maintaining the open passageway of the fetal ductus arteriosus |
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PGI 2
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produced in heart, vascular endothelial cells
causes inhibition of platelet aggregation, induces vasodilation |
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TXA 2
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produced by platelets
induces platelet aggregation and vascnstriction |
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LTC 4
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produced by monocytes, basophils, neutrophils, eisinophils, mast cells, epithelial cells
Compnonent of SRS-A, induces vasodilation and bronchoconstriction increases vascular permeability |
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LTD 4
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produced by monocytes and alveolar macrophages, eisinophils, mast cells, epithelial cells
is the predominant component of SRS-A2, induces vasodilation and bronchoconstriction increases vascular permeability |
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Omega 6 FA
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found in fish, peanut oil, and as suppliment
Produces group 1 and 2 prostoglandins and leukotrienes forms arachadonic acid linoleate acid |
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Omega 3 FA
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found in fish, peanut oil, and as a suppliment
forms group 3 prostanoids and leukotrienes alpha linolenate |
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Arachadonic acid
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produced by phospholipase A2 pathway, releases from phosphotidylcholine
in phospholipase C pathway, released from DAG and MAG by DAG and MAG lipase can produce cyclooxygenase and lipoxygenases produced from linoleate acid |
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Phospholipase A 2 pathway
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produces arachodonic acid from phosphotidylcholine
Ca is cofactor |
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Phospholipase C pathway
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produces arachodonic acid from DAG with DAG and MAG lipase
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Arachodonic acid byproducts
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5-lipoxygenase produces LTA4, LTE4, and LTB4
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LTA 4
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produced from arachadonic acid by 5-lipoxygenase
in leukocytes, platelets, mast cells, and heart and lung vascular tissues as LTE4, causes bronchoconstriction, increased vasculature permeability, and components of slow reacting substance of anaphylaxis as LTB4, causes increased chemotaxis of PMNs, release of lysosomal enzymes, and adhesion of WBCs |
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LTE 4
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produced from LTA4, first LTC4, then LTD4causes bronchoconstriction, increased vasculature permeability, and components of slow reacting substance of anaphylaxis
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LTB 4
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produced from LTA4, causes increased chemotaxis of PMNs, release of lysosomal enzymes, and adhesion of WBCs
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Aspirin
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irreversibly inactivates COX-1 and COX-2
used for treatment of stroke irreversibly inhibits production of TXA2 in platelets and PGI2 in endothelial vessels |
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COX 1
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constitutive cyclooxygenase
prodces PGG2 from arachadonic acid |
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PGG2
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produced from arachadonic acid by COX 1 and 2
GSH peroxidase produces PGH2, then TXA2, PGI2, PGF2, and PGE2 |
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COX 2
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non-constitutive enzyme
inhibited by apsirin corticosteroids, and selective inhibitors induced by cytokines, endotoxin, growth factor, tumor promotors |
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TXA 2 production by paltelets
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irreversibly inhibited by aspirin
leads to a decrease in platelet aggregation |
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PGI 2 production by endothelium cells
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inhibited by aspirin
can remake vasodilation and decreased platelet aggregation |
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lipoxygenase pathway
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produces leukotrienes, lipoxin, and hydroperoxy from arachadonic acid
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cyclooxygenase pathway
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produces prostoglandins and thromboxane from arachadonic acid
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