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11 Cards in this Set
- Front
- Back
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what is the biology of ehrlichia?
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gram neg, no LPS, no peptidoglycan, intracellular, morulae (membrane enclosed mass of bacteria)
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pathogenesis of ehrlichia?
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intracellular replication, survival in phagocytic vacuole, infects hemopoietic cells (possible anemia)
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what is the epidemiology of ehrlichia?
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lone star tick from white tail dear in southcentral US spreads E. chaffeensis. Ixodes tick from mouse and chipmunks in NE and central atlantic states spreads E. ewingii and E. phagocytophila. RAW FISH for E. sennetsu which is mainly in Japan.
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describe the disease of ehrlichiosis as caused by each of the species...
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chaffeensis attacks the monocytes and PMNs, get flu like symptoms, 50% get GI and 35% get a rash, immune system makes most of disease. ewingii is canine granulocytic ehrlichosis, humans are accidental host with a disease that is very similarr to monocytic ehrlchiosis. sennetsu has acute fever simillar to mono. anaplasma phagocytophilum causes human anaplasmosis (granulocytic), infects bone marrow neutros, get flu like, maybe GI and slim chance of rash
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how do you diagnose ehrlichiosis in lab?
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blood work will show thrombocytopenia, anemia, and leukmia, can do immunofluorescence serology, PCR 16s rRNA, cytology will show the morulae
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what is the treatment?
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doxycycline b4 lab confirmation...
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what is the biology of Coxiella burnetii?
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phase variation of LPS, obligate intracellular, phagolysosomal replication, forms spores that are released from infected cells, spores stay in environment for months
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what is the epidemiology of coxiella?
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worldwide, mostly disease of animals, humans get it from farm animal contact (inhalation of dried feces, animal placenta or ingestion of unpasteurized milk)
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what is the pathology of coxiella?
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infects resp tract and can disseminate to other organs, chronic infections often manifest to endocarditis. ONLY 1 ORG causes 50% of ppl to die.
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differentiate between an acute and chronic coxiella infection.
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acute is Q fever with headache, high fever, chills, myalgia, resp involvement that will mimc mycoplasma atypical pneumonia. chronic will result in subacute endocarditis on damaged heart valve
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how do you diagnose and treat coxiella?
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serology or PCR from reference labs. treatment is tetracycline
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