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20 Cards in this Set

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  • Back
if there is an association,
there is a higher freq of a specific allele in people with the disease
if there is a linkage,
two genes are inherited together in people with the disease
in brothers, if one x-linked gene is expressed...
all brothers wil either express the gene or all will not express the gene
lilenfeld found that family members of AN/BN probands are ___ more likely to have AN/BN
7-12x
3 types of quantitative studies
family, adoption, twin studies
model fitting analysis is a refinement of...
twin studies
heritability estimate
proportion of individual differences within a population that is due to genes
heritability estimate EQ
2(rMZ-rDZ)
if rMZ is twice rDZ
genetic effect
if rMZ = rDZ
shared
if rMZ < 1
nonshared
if rMZ = rDZ = 1
entirely shared
2 types of molecular studies
linkage, association
look directly at genomes/genes
molecular studies
examine patterns of relatedness
quantitative studies
find hot spots
linkage studies
examine specific gene
association studies
linkage is when...
...share forms of the marker (alleles) at greater than chance levels
lilenfeld found that relatives of people with AN and BN had increased risk for
MDD and OCD
lilenfeld found that the only diseases that showed transmission were
AN and OCPD