Ecvp Liver And Pancreas 2007-2009

Front 1

Where in normal liver, neonatal hepatitis and chronic hepatitis in dogs are the following proteins expressed?
1. tenascin-C (TN-C)
2. α-SMA
3. cytokeratin 7
4. CD3 (Tlymphocytes)
5. With what factors is tenascin-C correlated?

Back 1

1. normal: Disse's space and around bile ducts and blood vessels. NH: allong the reticular fibers that dissect the hepatocytes. CIRR: periphery of regenerating nodules andd fibours capsule.
2. normal: irregular perisinusoidal.
Other: incr. in fibrotic septa and perisinusoidal.
3. CK7 + bile ducts, in dieseased: portal-parenchymal interface, periphery of regenerative nodules, degenerated parenchyma.
4. CD3: inversely proportional to TN-C.
5. TN-C is correlated with fibrotic stage, inflammatory activity, expression of CK7 and α-SMA.

Hint 1

Vet pathol 44, 803-813 (2007)

Front 2

Copper-associated hepatitis in Labrador Retrievers.
1. Histologic lesions in the liver?
2. Copper levels and distribution?
3. Mode of inheritance in Bedlington terriers?
4. Other breeds with associated copper accumulation?

Back 2

1. multifocal, centrilobular and random, granulomas, hepatocellular necrosis, intrahepatic cholestasis, centrilobular or bridging fibrosis, occ. pseudolobe formation.
2. >2.000 ppm dw, cytoplasm of centrilobular and midzonal hepatocytes and macrophages.
3. Autosomal recessive deletion of COMMD1 gene: biliary excretion of copper down.
4. West Highland White, Skye, Dalmatian, Doberman pinscher.

Hint 2

Vet pathol 46, 484-490 (2009)

Front 3

The progenitor cell compartment in feline liver.
1. Where are the progenitor cells?
2. And in acute and chronic liver disease?
3. Staining characteristics for CK7, Hepar1 and MRP2?

Back 3

1. Lining the canals of Hering , same as dog and human.
2. ductular reaction, wether in parenchyma or in a portal or septal location.
3.CK7 + , Hepar and MRP2 -.

Hint 3

Vet pathol 46, 614-621 (2009)

Front 4

Multifocal granulomatous hepatitis in pigs caused by Actinobacillus pleuropneumoniae serotype 2.
1. Characteristics agent?
2. Histo?

Back 4

1. Gram -, facultative anaerobic, family pasteurellaceae.
2. granulomas with epithelioid macrophages, multinucleated giant cells, and asteroid bodies (Splendore-Hoeppli phenomenon).

Hint 4

CP 139, 61-66 (2008)

Front 5

Biliary cysts vs. peribiliary cysts in porcine liver.
1. Chg +?
2. Location?
3. Type of epithelial lining?
4. Connective tissue?
5. Influence on surroundings?

Back 5

1. Biliary cysts -, peri: some endocrine cells within wall +.
2. in hepatic parenchyma or interlobular connective tissue, vs large portal tracts often adjacent to noncystic peri= glands.
3. cuboidal vs. columnar to cuboidal to attenuated.
4. narrow, mature zone, vs, variable amount of variable maturity.
5. non, local compression and circulatory disturbance.

Hint 5

CP 139, 202-207 (2008)

Front 6

Ingestion of Tephrosia cinera in sheep.
1. Gross?
2. Histo liver?

Back 6

1. Hydrothorax, severe ascites, hydropericardium, hard and irregular liver.
2. chronic periportal and subcapsular fibrosis with bridging.

Hint 6

JVDI 19, 690-694, (2007)

Front 7

Vaccination with synthetic Sm14 protein of Schistosoma mansoni and challenge with F. hepatica in goat livers.
1. effect on worm burden?
2. differences in hepatic lesions?
3. which inflammatory cells were strikingly present?

Back 7

1. none
2. more severe bile duct hyperplasia in nonimmunized animals.
3. CD3+ T lympho's and IgG plasma cells: strong local cellular and humoral immune response.

Hint 7

CP 139, 169-176 (2008)

Front 8

Exocrine pancreatic carcinoma in dogs, an unusual variant: hyalinizing pancreatic adenocarcinoma.
1. Histo?
2. IHC?
3. Prognosis?

Back 8

1. Tubules and acini of epithelial cells, with bright eosinophilic granular apical cytoplasm. Lamina and stroma contain abundant eosinophilic material resembling amyloid.
1. noncongophilic, not birefringent,
- for amyloid A, immunoglobulin light chans, amylin, laminin, alpha1 antitrypsin (in clear-cell ductal panc. ac), PAS. Instead of dark blue, bluegray in Masson's trichrome (suggestive for collagen).
3. Prognosis seems better than in other pancreatic carcinomas.

Hint 8

Vet pathol 45, 475-483 (2008)