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32 Cards in this Set
- Front
- Back
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What is the MOA of imidacloprid and nitenpyram?
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competitive antagonist of nicotinic receptors
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What is the spectrum of Imidacloprid and Nitenpyram?
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adult fleas only
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What is different about Nitenpyram?
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oral, flea must bite to die
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What is the MOA of metaflumizone?
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Na channel blocker
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What is the spectrum of metaflumizone?
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flea adults only
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What is the MOA of spinosad?
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nicotinic receptor agonist
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What is the spectrum of spinosad?
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adult fleas only
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What is different about spinosad?
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oral product (Comfortis), flea must bite to die
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What is the MOA of lufenuron?
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chitin synthesis inhibitor
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What is the spectrum of lufenuron?
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egg and larval stages of flea, not adult
*use in combo with adulticides for treatment |
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What is the MOA of insect growth regulators?
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mimic juvenile hormone so fleas cannot become adults
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what are the insect growth regulators?
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methoprene
pyriproxyfen |
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What is the spectrum of insect growth regulators?
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egg and larval stages of fleas only
*use in combo with others to kill adults |
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What is the MOA of fipronil?
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blocks GABA and glutamate gated Cl channels
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What is the spectrum of fipronil?
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fleas and ticks (probably works against mites too, but not labelled for it)
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What is the MOA of selemectin?
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binds glutamate gated Cl channels to activate them
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What is the spectrum of selemectin?
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fleas, ticks, mites
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What is the MOA of pyrethrins/pyrethroids?
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prolongs Na conductance
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What is the spectrum of pyrethrins/ pyrethroids?
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fleas
ticks mites *repel or kill based on concentration |
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What is unique about pyrethrins/ pyrethroids?
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from Chrysanthemum plants, stability variable in UV light (pyrethroids better than pyrethrins)
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What species should NOT be given permethrin?
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cats (TOXIC!)
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What is the MOA of Carbamates and Organophosphates?
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inhibit AChE
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What is the spectrum of carbamates and organophosphates?
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nematodes, flies, fleas, ticks, mites
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What species is sensitive to organophosphates?
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cats
*don't let them go out on recently treated premises etc |
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What drug can be used to counteract organophosphate toxicity?
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atropine (only muscarinic, not nicotinic effects)
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What is the MOA of milbemycin?
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same as other macrocyclic lactones, potentiation of glutamate gated Cl channels
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What is the spectrum of Milbemycin?
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ear mites
(as well as nematodes etc) *otic preparation |
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What is the MOA of amitraz?
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MAO inhibitor
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What is the spectrum of amitraz?
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mites, ticks
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What is the safety margin of amitraz?
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fairly toxic, pay attention to dose and wear gloves etc while handling
*alpha-2 agonist as well so can cause sedation, altered BP |
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Which agencies regulate ectoparasiticides?
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EPA (topical), FDA (anything that acts systemically)
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What are the AMDUCA rules about ectoparasiticides?
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cannot use extra-label because they are not approved drugs!
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