E/c Matrix

Front 1

Glycoaminoglycans (definition)

Back 1

polysaccharides composed of repeating (identical) disaccharide units

heoxamino sugar (N-acetylglucosamine or N-acetylgalactosamine) one of repeating disaccharide

Front 2

GAG (properties)

Back 2

GAGs often sulfated with uronic acid sugar (negatively charged)

GAG = strong negative charge

Front 3

GAG (examples: 4x)

Back 3

1. Hyaluornic acid (unsulfated)

2. Chondroitin sulfate and dermatan sulfate

3. Heparin and Heparan sulfate

4. Keratan sulfate

Front 4

Proteoglycan (Def)

Back 4

GAG attached to a core protein: bottlebrush model

Ex: chondroitin sulfate; heparin; keratan sulfate

Front 5

Proteoglycan (function, 2x)

Back 5

1. Binding site for growth factors/signalling molecules

2. Filtration properties: glomerulus

Front 6

Glycoproteins (def)

Back 6

Multifunctional molecules; domain binds between cell surface and e/c matrix promoting adhesion

Front 7

Glycoproteins (types and function, 6x)

Back 7

1. Fibronectin: domains binding collagen, heparin, cell adhesion molecules

2. Laminin: located in basal laminae; cross shaped; mediates interaction b/t epithelial cells and basal lamina; syn by epithelial cells

3. Entactin: component of basal lamina; binds laminin; links laminin with type IV collagen

4. Tenascin: abundant in embryonic tissue; promotes cell-matrix adhesion and cell migration

5. Chondronectin: glycoprotein binds type II collagen; development and mantain. of cartilage

6. Osteonectin: synthesized by osteoblasts; binding site for integrins; role in bone formation and remodeling

Front 8

Fibronectin receptors (properties and funx)

Back 8

Properties: integrin family of receptors, 2 polypeptide echains

Function: enable cells to adhere to e/c matrix (CAMs)

Front 9

Type IV Collagen

Back 9

1. Basement membrane

2. Propeptide sequences are not removed

3. Forms head-head dimers

Front 10

Elastin

Back 10

Protein which imparts elasticity on ECM.

Lysine molecules form unique linkages with one another

Associated with fibrillin; a glycoprotein which organizes elastin and main component of the peripheral microfibrils.

Front 11

Scurvy (Cause + Symptoms)

Back 11

Symptoms: bleeding gums and tooth loss

Cause: synthesis of poorly hydroxylated tropocollagen due to vitamin C deficiency

Front 12

Wound healing (Process, 2x)

Back 12

1. Connective tissue: wound healing characterized by migration of fibroblasts across blood clots where they adhere to fibronectin

2. Epithelium. Basal lamina as a scaffold for cell migration to cover exposed area.

Front 13

Ehlers Danlos Type IV (Symptoms, Cause)

Back 13

Symptoms: Translucent skin, easy ruptured bowel/large arteries

Cause: Genetic defect in transcription of type III collagen (= few reticular fibers)

Front 14

Marfan syndrome (symptom, cause)

Back 14

Symptoms: Lens of eye dislocates, aortic rupture

Cause: Mutation in fibrillin (protein associate with elastin)