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26 Cards in this Set

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How can you tell an intrauterine pregnancy from an ectopic with ultrasound and b-hCG levels
IUP should be seen on transvaginal US w/b-hCG between 1500 and 2000; fetal heartbeat should be seen with b-hCG > 5000
Rx for a hemodynamically unstable ectopic pregnancy
Stabilize with IV fluids, blood, pressors

Then do exploratory laparotomy to remove ectopic
What is the major treatment tool used for a stable ectopic
methotrexate or exploratory laparoscopy to remove hemoperitoneum, coagulate ongoing bleeding, resect ectopic --> salpingostomy, salpingectomy, cornual resection (interstitial ectopic)
When is methotrexate indicated as treatment for an ectopic?

what should you monitor and when is a second dose indicated
small ectopics (<4cm, w/o fetal heartbeat), patients who are stable and will be reliable w/followup

Monitor transaminases and creatinine, serially follow b-hCG

if b-hCG does not fall by 10-15% between 4-7 days of treatment, give a second dose
What is a spontaneous abortion
pregnancy that ends before 20 weeks
Definition

abortus
fetus lost before 20 weeks gestation, <500g, or <25cm
What is the difference between a complete abortion and an incomplete abortion
complete = complete expulsion of all products of conception before 20 wks

incomplete = partial epulsion
What is the difference between an inevitable abortion and a threatened abortion
inevitable = no expulsion of products, but vaginal bleeding and dilation of the cervix so viable pregnancy is unlikely

threatened = vaginal bleeding before 20 wks, w/o dilation of cervix or expulsion of POC
What is a missed abortion
death of the embryo/fetus before 20 weeks, complete retention of all POC
Majority of first trimester abortions are due to what
60-80% due to abnormal chromosomes
6 things on the differential for first trimester bleeding
-Spontaneous abortion
-Postcoital bleeding
-Ectopic pregnancy
-Vaginal/cervical lesions or lacerations
-Extrusion of molar pregnancy
-Nonpregnancy causes of bleeding
Rx for an incomplete abortions, inevitable and missed abortions
1. Finish on its own
2. D&C
3, Misoprostol to induce cervical dilation and uterine contractions
Rx for threatened abortion

What 2 conditions are these patients at risk for
Follow for bleeding, place on pelvic rest w/nothing per vagina

Increased risk for preterm labor, preterm premature rupture of membranes
5 common etiologies for second trimester abortions
Infection
Maternal uterine/cervical anatomic defects

Maternal systemic disease

Fetotoxic agents

Trauma
How do you treat Incomplete or missed abortions between 16-24 weeks
Dilation and evacuation (must aggressively dilate with laminaria)

OR

Induced labor with oxytocin or prostaglandins
What is the difference between Pre-term labor and incompetent cervix (as etiologies of incomplete or threatened abortions in 2nd trimester)? How do you treat them differently?
PTL - contractions --> cervical change; manage with cerclage

Incompetent cervix - painless dilation of the cervix; manage with tocolysis
What happens when a patient as an incompetent cervix?
Findings?

What does it normally cause problems
15% of all second trimester losses

Painless dilation and effacement of the cervix --> fetal membranes exposed to vaginal flora --> increased risk of trauma, infection

FIndings: infection, vaginal discharge, rupture of membranes, cramping, chorionic/amniotic sacs bulging through cervix
Risk factors for incompetent cervix (4)
History of cervical surgery
History of cervical lacerations (in a vaginal delivery)
Uterine anomalies
History of DES exposure
What is the etiology of pain associated with an incompetent cervix as opposed to pre-term labor
incompetent cervix - dilated cervix with exposed membranes

pre-term labor - contractions/cramping leading to cervical change
How do you treat previable (<24wks) cervical incompetence
1. Possible expectant management
2. Elective termination
How do you treat patients with viable pregnancies with cervical incompetenece
betamethasone (decrease risk of prematurity), bed rest

Tocolysis if preterm contractions
What is a cerclage?

When is it used?

2 types?
suture placed around the cervix

cervical-vaginal jn (McDonald) or internal os (Shirodkar)

Used in previable pregnancy w/incompetent cervix
What is the management procedure if a patient has a failed vaginal cerclage
transabdominal cerclage - placed aroundt he cervix at the level of the internal os in a laparotomy
What is a recurrent pregnancy loss
woman with 3 or more consecuative spontaneous abortions
What is antiphospholipid antibody syndrome?

Luteal phase defect?

what do both of these predispose to?
APA syndrome -

Luteal phase defect - lack adequate progesterone

Recurrent pregnancy loss
What is the screening procedure for a woman with recurrent pregnancy loss
(5)
1. karytype analysis of bothe parents, previous conceptuses if possible
2. examine female anatomy with a hysterosalpingogram
3. screen for hypothyroidism, DM, Anti-phospholipi Ab syndrome, hypercoag, SLE
4. Serum progesterone measured during luteal phase
5. culture cervix, vagina, endometrium