E4 Opiates And Anti-Inflammatory Review

Front 1

NSAIDs inhibit the enzyme ________, they are known as COX-inhibitors.

Back 1

Cyclooxygenase

Front 2

Salicylates include ______.

Back 2

Aspirin

Front 3

Acetaminophen, Ibuprofen, and Naproxen are referred to as ______ NSAIDs.

Back 3

Traditional

Front 4

Traditional NSAIDs were developed after it was discovered that earlier NSAIDs irritated the ________ system and caused ______.

Back 4

Gastrointestinal
Stomach Bleeding.

Front 5

What enzyme is required for gastrointestinal function?

Back 5

Cyclooxygenase-1 (COX-1)

Front 6

Earlier NSAIDs were nonselective and blocked the _______ enzyme cause significant GI problems.

Back 6

COX-1

Front 7

Selectively blocking COX-2 enzymes alleviate pain by reducing the production of _______.

Back 7

Prostaglandins

Front 8

COX-2 inhibitors

Back 8

Celecoxib, Rofecoxib, Valdecoxib

Front 9

Rofecoxib and Valdecoxib were discontinued after it was discovered to be linked to _______ in patients taking these drugs on daily basis.

Back 9

Heart attacks

Front 10

Corticoid steroid are able to inhibit _____ which is why they are widely used as anti-inflammatories.

Back 10

PLA

Front 11

Opiates receptors are ______.
They contain _____ transmembrane segments.

Back 11

Metabotropic
Seven

Front 12

Nociceptin
(Mu receptors/Delta receptors/Kappa receptors/Nociceptin receptors)

Back 12

Nociceptin receptor

Front 13

Naloxone
(Mu receptors/Delta receptors/Kappa receptors/Nociceptin receptors)

Back 13

Mu receptors
Delta receptors
Kappa receptors

Front 14

Quinolone
(Mu receptors/Delta receptors/Kappa receptors/Nociceptin receptors)

Back 14

Nociceptin receptors

Front 15

Cyprodime
(Mu receptors/Delta receptors/Kappa receptors/Nociceptin receptors)

Back 15

Mu receptors

Front 16

Deltorphins
(Mu receptors/Delta receptors/Kappa receptors/Nociceptin receptors)

Back 16

Delta receptors

Front 17

Endorphins
(Mu receptors/Delta receptors/Kappa receptors/Nociceptin receptors)

Back 17

Mu receptors

Front 18

Naltrexone
(Mu receptors/Delta receptors/Kappa receptors/Nociceptin receptors)

Back 18

Mu receptors
Delta receptors
Kappa receptors

Front 19

Enkephalins
(Mu receptors/Delta receptors/Kappa receptors/Nociceptin receptors)

Back 19

Delta receptors

Front 20

Dynorphins
(Mu receptors/Delta receptors/Kappa receptors/Nociceptin receptors)

Back 20

Kappa receptors

Front 21

Diprenorphine
(Mu receptors/Delta receptors/Kappa receptors/Nociceptin receptors)

Back 21

Mu receptors
Delta receptors
Kappa receptors

Front 22

Naltriben
(Mu receptors/Delta receptors/Kappa receptors/Nociceptin receptors)

Back 22

Delta receptors

Front 23

Quadazocine
(Mu receptors/Delta receptors/Kappa receptors/Nociceptin receptors)

Back 23

Kappa receptors

Front 24

Analgesic effects are mediated by what types of receptors?

Back 24

Mu receptors

Front 25

Respiratory suppressant effects are mediated by what types of receptors?

Back 25

Delta receptors

Front 26

Sedation effects are mediated by what type of receptors?

Back 26

Kappa receptors

Front 27

Sensation of pain are mediated by what types of receptors?

Back 27

Nociceptin receptors

Front 28

Appetite suppressant effects are mediated by what types of receptors?

Back 28

Kappa receptors

Front 29

Cough suppressant effects are mediated by what types of receptors?

Back 29

Mu receptors

Front 30

Antidepressant effects are mediated by what types of receptors?

Back 30

Delta receptors

Front 31

COX-2 inhibitors have no effect in the ___ system.
They're active in inflammatory events, and ______ functions.

Back 31

GI
Cardiovascular

Front 32

Analgesia and Anti-inflammatory synthesis

Back 32

PIP2 -----> PLA/corticosteroid inhibition > arachadonic acid ----> COX-1 or COX-2 > prostaglandins: vanilloid receptors, ASICs, etc > free radicals

Front 33

Opioids antagonist ligands

Back 33

Naloxone, Naltrexone, Diprenorphine

Front 34

Opioids endogenous ligands

Back 34

Endorphins, deltorphins, enkephalins, dynorphins, nociceptin

Front 35

Endorphins

Back 35

Endogenous Ligand for Mu receptors

Front 36

Deltophins and Enkephalins

Back 36

Endogenous ligands for Delta receptors

Front 37

Dynorphins

Back 37

Endogenous ligand for Kappa receptors

Front 38

Nociceptin

Back 38

Endogenous ligand for Nociceptin receptors

Front 39

Exogenous opium alkaloids

Back 39

Morphine (most potent)
Codeine
Thebaine
Narcotine (weakest)
Papaverine

Front 40

Modified Opiates

Back 40

Diacetylmorphine
Hydromorphone
Oxycodone
Hydrocodone

Front 41

Synthetic Opiates

Back 41

Buprenophrine
Methadone
Meperidine
Propoxyphene
Fentanyl
Sufentanil

Front 42

Buprenophrine

Back 42

Partial Agonist
Long Acting (days)

Front 43

Methadone

Back 43

Long Acting (days)

Front 44

Meperidine

Back 44

Medium action (hours)

Front 45

Propoxyophene

Back 45

Weak
Medium action (hours)

Front 46

Fentanyl

Back 46

Short acting (minutes)

Front 47

Sufentanil

Back 47

Short acting (minutes)

Front 48

Opiate antagonist for OD Tx

Back 48

Naloxone
Naltrexone
Diprenorphine