E3 Biogenic Amines Ii: Ne And Epi Review

Front 1

The major source if norepinephrine in the CNS is in the _______.

Back 1

Local Coeruleus

Front 2

"Release Blockers"

Back 2

Guanethidine
Guanadrel
Bretylium

Front 3

Guanethidine
(Antiarrhythmic/Antihypertensive)

Back 3

Antihypertensive

Front 4

Guanadrel
(Antiarrhythmic/Antihypertensive)

Back 4

Antihypertensive

Front 5

Bretylium
(Antiarrhythmic/Antihypertensive)

Back 5

Antiarrhythmic

Front 6

These "release blockers" work by acting on the ________ pump necessary for the storage of NE into vesicles.

Back 6

Proton

Front 7

The proton ATPase responsible for the storage of NE into vesicles is a ________ ATPase.

Back 7

Mg2+

Front 8

The substrate for this magnesium ATPase is ________.

Back 8

ATP

Front 9

The cofactors for this magnesium ATPase are _________ and __________.

Back 9

Protons, Magnesium

Front 10

Atomoxetine inhibits the reuptake of _________.
(DA/NE/5-HT)

Back 10

NE

Front 11

Reboxetine inhibits the reuptake of _________.
(DA/NE/5-HT)

Back 11

NE

Front 12

Indatraline inhibits the reuptake of __________.
(DA/NE/5-HT)

Back 12

DA, NE, 5-HT

Front 13

Cocaine inhibits the reuptake of _________.
(DA/NE/5-HT)

Back 13

DA, NE, 5-HT

Front 14

Amineptine inhibits the reuptake of ___________.
(DA/NE/5-HT)

Back 14

DA

Front 15

Bupropion inhibits the reuptake of __________.
(DA/NE/5-HT)

Back 15

DA, NE

Front 16

Imipramine inhibits the reuptake of ___________.
(DA/NE/5-HT)

Back 16

NE

Front 17

Nomifensine inhibits the reuptake of __________.
(DA/NE/5-HT)

Back 17

DA, NE

Front 18

Methylphenidate inhibits the reuptake of __________.
(DA/NE/5-HT)

Back 18

DA

Front 19

Amphetamine inhibits the reuptake of ___________.
(DA/NE/5-HT)

Back 19

DA

Front 20

Venlafaxine inhibits the reuptake of ___________.
(DA/NE/5-HT)

Back 20

NE, 5-HT

Front 21

Duloxetine inhibits the reuptake of ___________.
(DA/NE/5-HT)

Back 21

NE, 5-HT

Front 22

Amitriptyline inhibits the reuptake of ____________.
(DA/NE/5-HT)

Back 22

NE

Front 23

Venlafaxine and Duloxetine are commonly prescribed as _________.

Back 23

Anti-depressants

Front 24

Atomoxetine is commonly prescribed as a treatment for ___________.

Back 24

ADD or ADHD

Front 25

Atomoxetine and Reboxetine are commonly known as __________ drug.

Back 25

Atypical

Front 26

Imipramine and Amitriptyline are commonly known as __________.

Back 26

Tricyclic antidepressants

Front 27

Befloxatone
(A-specific (NE, 5-HT)/AB-specific (nonspecific)/B-specific (DA, HA)/Neither)

Back 27

A-specific (NE, 5-HT)

Front 28

Harmaline
(A-specific (NE, 5-HT)/AB-specific (nonspecific)/B-specific (DA, HA)/Neither)

Back 28

A-specific (NE, 5-HT)

Front 29

Iproniazid
(A-specific (NE, 5-HT)/AB-specific (nonspecific)/B-specific (DA, HA)/Neither)

Back 29

A/B-specific (nonspecific)

Front 30

Deprenyl
(A-specific (NE, 5-HT)/AB-specific (nonspecific)/B-specific (DA, HA)/Neither)

Back 30

B-specific (DA, HA)

Front 31

Tolcapone
(A-specific (NE, 5-HT)/AB-specific (nonspecific)/B-specific (DA, HA)/Neither)

Back 31

Neither

Front 32

What degradation inhibitors are MAO-Is?

Back 32

Befloxatone
Harmaline
Iproniazid
Deprenyl

Front 33

What degradation inhibitors are the COMT-Is?

Back 33

Tolcapone

Front 34

What degradation inhibitors are reversible?

Back 34

Befloxatone

Front 35

What degradation inhibitors are irreversible?

Back 35

Harmaline
Iproniazid
Deprenyl
Tolcapone

Front 36

Deprenyl is now widely used on patients suffering from _________ phase III because many of these patients also suffer from depression.

Back 36

Alzheimer's

Front 37

Alpha 1 receptors are tied to a __________.
(Gq/Gi/Gs)

Back 37

Gq

Front 38

Alpha 2 receptors are tied to a ___________.
(Gq/Gi/Gs)

Back 38

Gi

Front 39

Beta receptors are tied to a ____________.
(Gq/Gi/Gs)

Back 39

Gs

Front 40

Gq up regulates ________; increases the activity of ________.

Back 40

PLC
PKC

Front 41

Gi down regulates ________; decreases the activity of _________.

Back 41

AC
PKA

Front 42

Gs up regulates ________; increases the activity of ________.

Back 42

AC
PKA

Front 43

Dopamine
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 43

Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs

Front 44

Norepinephrine
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 44

Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs

Front 45

Epinephrine
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 45

Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs

Front 46

Tetrahydrozoline
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 46

Alpha 1A Rs

Front 47

Phentolamine
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 47

Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs

Front 48

Clonidine
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 48

Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs

Front 49

Phenylephrine
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 49

Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs

Front 50

Prazosin
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 50

Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs

Front 51

LSD-25
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 51

Alpha 2A Rs

Front 52

Corynanthine
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 52

Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs

Front 53

Yohimbine
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 53

Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs

Front 54

Phenoxybenzamine
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 54

Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs

Front 55

Isoproterenol
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 55

Beta 1 Rs/Beta 2 Rs/Beta 3 Rs

Front 56

Clenbuterol
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 56

Beta 1 Rs/Beta 2 Rs/Beta 3 Rs

Front 57

Xamoterol
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 57

Beta 1 Rs

Front 58

Albuterol
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 58

Beta 2 Rs

Front 59

Salmeterol
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 59

Beta 2 Rs

Front 60

Atenolol
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 60

Beta 1 Rs

Front 61

Butoxamine
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 61

Beta 2 Rs

Front 62

Propranolol
(Alpha 1A Rs/Alpha 1B Rs/Alpha 1D Rs
Alpha 2A Rs/Alpha 2B Rs/Alpha 2C Rs
Beta 1 Rs/Beta 2 Rs/Beta 3 Rs)

Back 62

Beta 1 Rs/Beta 2 Rs/Beta 3 Rs

Front 63

What are the three endogenous ligands?

Back 63

Dopamine
Epinephrine
Norepinephrine

Front 64

Phenylephrine is commonly used as a _____________.

Back 64

Nasal Decongestant

Front 65

Tetrahydrozoline is commonly found in __________.

Back 65

Eye Drop

Front 66

Clonidine is widely used as an __________ drug.

Back 66

Anti-hypertensive

Front 67

Phentolamine and Prazosin are commonly used as __________ drugs.

Back 67

Anti-hypertensive

Front 68

Does clonidine cross the BBB?

Back 68

Yes

Front 69

Does phentolamine cross the BBB?

Back 69

No

Front 70

Does prazosin cross the BBB?

Back 70

No

Front 71

Albuterol is commonly used on patients suffering from _________.

Back 71

Asthma

Front 72

Salmeterol is commonly used on patients suffering from __________.

Back 72

Chronic Asthma