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17 Cards in this Set
- Front
- Back
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most (65%) of the ciruclating testosterone is bound to ___
most of the rest is bound to ___ % of testosterone that is free |
sex hormone binding globulin (SHBG)
albumin ~2% |
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enzyme that catalyzes the conversion of testosterone to dihydrotestosterone
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5 alpha reductase
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enzyme that catalyzes the conversion of testosterone to estradiol
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P450 aromatase
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the 3 major peaks of androgen production during life
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embryonic development
neonatal period (~1 year) onset of puberty |
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5 general uses for androgen administration
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replace engodenous androgen secretion in hypogonadal men
hypopituitarism at puberty (to induce puberty) maintain sexual characteristics in those w/ testicular failure enhancement of athletic performance treat endometriosis |
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route of administration that is rapidly absorbed but also rapidly metabolized
other routes are usually needed |
oral
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testosterone that provides for the best profile of serum testosterone levels
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testosterone topical gel
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3 testosterone esters
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testosterone propionate
testosterone cypionate testosterone enanthate |
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forms of testosterone that are used to replace endogenous androgen secretion in hypogonadal men
goal of therapy? |
transdermal testosterone (gel or patch) or the esters (3)
mimic normal serum concentrations |
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androgen drug that is used to treat endometriosis
inhibits gonadotropin release at the hypothalamus no FSH/LH surge at midcycle causes atrophy of ectopic endometrial tissue |
danazol
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parenteral anabolic steroid occasionally used to manage anemia of chronic renal failure and for osteoporosis
pretty much only abused now Roger Clemens has been implicated in the use of this drug |
nandrolone
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orally administered synthetic testosterone derivative
promotes skeletal muscle protein synthesis through stimulation of tesosterone or DHT receptors can promote weight gain following burns or trauma |
oxandrolone
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adverse effects that are more likely to be caused by 17 alpha alkylated products
these include methyltestosterone, oxandrolone, stanozolol, and danazol |
hepatic dysfunction, increased LDL, and decreased HDL
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3 absolute contraindications to androgen replacement
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pregnancy
infants and young children prostate or breast carcinoma |
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3 androgen receptor antagonists
used to treat metastatic prostate cancer |
flutamide
bicaluatimde nilutamide |
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aldosterone inhibitor and weak inhibitor of testosterone synthesis
used for treatment of hirsutism in women |
spironolactone
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5 alpha reductase inhibitors (2)
blocks synthesis of DHT used to treat BPH, male patterned badness, and hirsutism |
finasteride
dutasteride |
