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8 Cards in this Set
- Front
- Back
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What percent of the pancreas is endocrine? Where does it secrete into?
Exocrine? |
2% of gland mass
Insulin, glucagon, somatostatin, etc Secreted directly into vessels 85% of gland mass - enzymes secreted as inactive zymogens (trypsin, chymotrypsin, amylase, lipase, etc) - acini drain into pancreatic ducts |
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Which cells in pancreas contain zymogen granules, and have basal nuclei?
Cells w/ central nuclei and non-granular cytoplasm? What are the 4 major islet cell secretory types and their relative % prevalances? |
acinar cells.
islet cells. a - glucagon (20%) B - insulin (70%) d - somatostain (8%) D1 - vasointestinal polypeptide (1%) |
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Is Type II diabetes mellitus characterized by islet inflammation?
Is Amyloid deposition in the pancreas seen often in Type II diabetics? Is it specific to this dz? In which group is this more prevalent? - what is the protein, specifically? |
No.
Yes, no. The elderly. - amylin, a protein secreted w/ insulin. |
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What are the origins of pancreatic endocrine tumors?
- represent what % of pancreatic tumors? - majority fx? - list relative prevalances of those that *are* fx. - may be a part of which genetic defect syndromes? |
multipotent ductular stem cells.
- 1-3% - no, maj. = non-functional - insulinoma > gastrinoma > (VIPoma, glucagonoma, somatostatinoma, etc.) - MEN syndromes |
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Which are more clinically indolent, pancreatic endocrine tumors or ductal adenocarcinomas?
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pancreatic endocrine tumors.
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which of the fx pancreatic endocrine tumors secretes it's product ectopically?
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gastrinoma. G cells aren’t native to the islet! So this is considered ectopic when they do show up in the pancreas and start secreting.
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Are cytologic markers good indicators of malignancy in pancreatic endocrine tumors?
Are the majority of insulinomas benign or malig? Other fx tumors? |
no, histology is a poor predictor of behavior.
benign (90%). others are more likely to recur/metastasize... esp. Gastrinoma. |
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Are islets cells more common in the head or the tail of the pancreas? Where are most islet tumors found?
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tail. tail.
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