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32 Cards in this Set
- Front
- Back
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What is the gram stain morphology of campylobacter and helicobacter?
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Spiral Gram Neg
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What features are unique to both Campy and Helicobacter?
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-Low GC content
-Can't ferment or oxidize carbs -Microaerophilic |
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What types of disease does Campylobacter cause?
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Gastrointestinal distress in animals and humans.
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What does the gastrointestinal distress consist of?
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-Diarrhea
-Abdominal pain -Fever -Nausea -Vomiting |
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What is the diarrhea like in Campylobacter infections?
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Bloody
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What follows 10-20% of Campylobacter cases of GI distress?
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Relapsing colitis that mimics Crohn's disease
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What is the worst sequelae that can develop following Campy diarrheal illness?
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Guillain Barre
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When does Guillain-Barre syndrome develop?
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2-3 weeks after diarrheal illness
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What is the natural reservoir for Campylobacter?
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Chicken juice
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What are the 2 major pathogenic species of Campylobacter?
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C. jejuni
C. coli |
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What is required for campylobacter growth in culture?
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-Microaerophilic environment
-42 degrees |
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Is Campy motile?
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Yes - darting motility
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Is there only one type of Campy?
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No there are 10 O-serogroups
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What is the infectious dose of Campy?
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Very low - it only takes a couple drops of chicken juice, or 800 bacteria
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What is the average incubation time before symptoms develop?
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2-4 days
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Where does Campy multiply in the body?
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In the small and large intestines
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What do the symptoms of campylobacter GI distress mimic?
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Ulcerative colitis
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How common is GI distress due to Campylobacter?
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More often than Salmonella or Shigella infections.
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When are the highest isolation rates for Campy, and how is it transmitted?
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-Highest in summer
-Transmitted by contamined food from poultry |
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Does H. pylori exhibit the same seasonal variation like C. jejuni?
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no
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At what age do C. jejuni infections spike and fall back down?
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From 20-35 - when young adults first learn how to barbecue
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When do H. pylori infections increase?
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Gradually and continually as you age
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What is the prevalence of H. pylori infection by the age of 60?
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60%
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What are the 5 organisms responsible for foodborne illnesses in order of most causative to least?
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1. Campy
2. Salmonella 3. Shigella 4. Ecoli 0157H7 5. Yersinia |
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What is the toxin produced by campylobacter?
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CDT
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What is CDT? What does it do?
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Cytolethal distending toxin - interrupts the cell cycle progression.
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What other bugs have cdt genes?
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-Shigella dysenteriae
-E. coli |
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Do we know how the CDT toxins work?
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no not really
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How is Campylobacter identified?
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-Darting motility in fresh fecal samples
-PCR |
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How is Campy infection treated?
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-Fluid replacement
-Electrolyte balance |
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Why is antimicrobial treatment of Campy reserved for patients with advanced or severe infections?
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Because resistance has developed due to farmers giving their animals antibiotics in feed.
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What are the drugs of choice for campy infections?
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-Erythromycin
-Fluoroquinolones -Tetracycline |
