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34 Cards in this Set
- Front
- Back
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shigella infects what part of the GI tract
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terminal ileum and large intestine
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transmission of shigella
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fecal-oral
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reservoir of shigella
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humans
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clinical signs of shigella infection
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sudden abdominal pain
diarrhea fever |
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infectious dose of shigella
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low (due to resistance to stomach acid)
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species of shigella that contain shiga toxin
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shigella dysenteriae
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species of shigella that is most common in industrialized countries
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shigella sonnei
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mechanism of shiga toxin
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cleaves the 60S ribosome resulting in apoptosis
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shigella enters what cells in the gut
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M cells (due to inadequate glycocalyx layer)
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why is the M cell the target of invasion for shigella
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reduced glycocalyx layer
rudimentary brush border |
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hallmark of inflammatory diarrhea
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presence of neutrophils in clumps of mucus
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salmonella infects what part of the GI system
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ileum
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two clinical syndromes caused by salmonella
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gastroenteritis
typhoid fever |
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antigens present on salmonella that classification is based off of
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O and H
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transmission of salmonella
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ingested in foods or contaminated water
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strains of salmonella that cause typhoid fever
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typhi
paratyphi |
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strains of salmonella that cause gastroenteritis
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cholerasuis
enteritidis dublin |
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reservoir for salmonella typhi and paratyphi
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humans
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most frequent manifestation of salmonella infection
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gastroenteritis
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dose required for infection from salmonella
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high (susceptible to pH)
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exudative inflammatory infiltrates in the intestines that are dominated by a massive neutrophil influx
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salmonella gastroenteritis
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systemic illness due to salmonella that can lead to bacteremia
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typhoid fever
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tyhpoid fever is spread through what
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lymphatics
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high fever
abdominal pain transient diarrhea rash on trunk |
typhoid fever
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hypertrophy of peyers patches, mesenteric lymph nodes, spleen and bone marrow
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typhoid fever
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salmonella typhi eventually infect what
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gallbladder (and grow in the bile)
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salmonella invades enterocytes by what mechanism
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bacterial mediated endocytosis
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salmonella injects toxin by what mechanism
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type III secretion system
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toll like receptor ligands contained on salmonella
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LPS (activates TLR4)
flagellin (activates TLR5) |
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importance of TLR activation
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NFkB (recuits cytokines and macrophages)
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how are salmonella taken from the enterocyte to the lymph nodes
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they enter macrophages (in the lamina propria)
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transport salmonella to the mesenteric lymph nodes
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macrophages
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4 different species of shigella
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dysenteriae
flexneri boydii sonneii |
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shigella classification is based on what
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O antigen
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