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37 Cards in this Set
- Front
- Back
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Description: DPIs
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DPIs dispense a powder in a stream of inspired air.
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The force of powderflow for DPI comes from where?
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The inspiratory efforts of the patient
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The formulation for a DPI usually consist of....
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drug and carrier powder
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What is a problem that can occur when drug powders get to small (micronize)?
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The can become cohesive and adhesive and can stick to each other and or the device.
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T or F
Carrier powders are smaller particles that "carry" the larger particles. |
False. Larger particles that carry the smaller particles
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What is the function of carrier powders?
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They function to improve powder flow and dispersability.
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Name two examples of carrier powders.
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Lactose and glucose
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What are the consequences of the carrier powder?
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They will be less respirable - they will impact and be swallowed.
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What are the three unit dose categories discussed in class and there brand names?
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Rotahaler (Ventolin), HandiHaler(Spiriva) and Aerolizer (Foradil)
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What is Ventolin? How is it used?
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It is a unit dose DPI that falls under that category of Rotohaler.
The capsule is broken open in the device and inhaled through a screened tube. |
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Where is the capsule punctured in the Handihaler?
What is a brand name? |
The capsule is punctured on the side in the device and teh powdered is inhaled through a screened tube
Spriva |
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The capsule is punctured on each end in this unit dose DPI and the powder is inhaled through a screened tube?
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Aerolizer
Brand name: Foradil |
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What are two examples of multiple unit-dose DPIs?
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-Diskhaler
-Diskus |
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What is an example of a diskhaler?
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Relenza
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Describe the contents in a dishaler?
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Contains a circular disk that contains powdered charges seperately packed in aluminum blister packed which are pierced before inhalation
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Serevent and Advair falls under this class of DPI.
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Multiple unit-dose --Diskus
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Describe the characteristics of multiple dose DPIs
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The container has a reservoir of drug, from which doses are metered into an inhalation chamber
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Name two types of multiple dose DPIs.
In which one does one have to twist until there is a clicking sound? |
Pulmicort Flexihaler (*) and Asmanex Twisthaler
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Asmanex Twisthaler shelf life is ?
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45 days after opening (moisture sorption)
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Key Feature of a nebulizer?
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The product is admistered during a normal breathing pattern.
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What are two general types of nebulizers?
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Air Jet and Ultrasonic
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How many thypes of air jet nebulizers are there?
What are they? |
3
Coventional, Manual Flow interrupter and Open Vent |
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How long are nebulizers issued for?
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7-10 minutes
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What is an example of a Manual flow interrupter jet nebulizer?
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Pari LL nebulizer
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This type of nebulizer "allows patients to exercise control over the inflow of compressed air" thereby the patient can match nebulization with inhalation.
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Manual flow interrupter jet nebulizer
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Describe the "Open vent" jet nebulizer
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It has an additional vent in the nebulizer chamber, which allows more air to be sucked into the nebulizer, which increase teh airflow out of teh nebulizer
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What release aerosol products in an ultrasonic nebulizer?
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Geysers
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T or F
Both types of nebulizers can produce aerosols less then 5 microns |
True. This is important fpr deep lung penetration.
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Which type of nebulizer is somewhat more efficient at aerosol delivery?
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Ultrasonic
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Describe the tempurature differences between the nebulizers
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Jet tends to cool (evaporative)
Ultrasonic tends to heat |
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Why may a solution become more concentrated during nebulization?
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Water evaporation
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What type of nebulizer produce more effiencient particles of Pentamine for P. Carinii
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Ultrasonic-larger particles but more efficient
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Why can't one use ultrasonic nebulizer for Dornase alfa?
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It has been found to cause protein denaturation
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Why is jet nebulizers only used for Pulmicort respule?
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Because they are better at deaggregating the suspensoid
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What the pH for nebulizer solutions is below 5?
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Risk of brronchospasms
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Solutions with out presevatives are used for what type of dose?
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Single dose
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Why should drug products buffer capacity be limited?
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So that it would not overwhelm the bodies own
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