Drugs Used In Treatment Of Tuberculosis

Front 1

types of TB therapy

Back 1

preventative
tx of active disease

Front 2

classification of 1st versus 2nd line drugs is based on what

Back 2

efficacy
risk of drug toxicity

Front 3

first line TB drugs

Back 3

streptomycin
rifampin
isoniazid
pyrazinamide
ethambutol

Front 4

first line drug with a lot of side effects and that is not used often as first line

Back 4

streptomycin

Front 5

1st line drug that provides coverage for rifampin and isoniazid resistant TB

Back 5

ethambutol

Front 6

TB drugs that have a 95% cure rate in 9 mo

Back 6

rifampin
isoniazid

Front 7

TB drugs that inhibit the cell wall

Back 7

isoniazid
ethambutol

Front 8

TB drugs that inhibit protein synthesis

Back 8

pyrazinamide

Front 9

TB drug that inhibits RNA synthesis

Back 9

rifampin

Front 10

reasons TB is hard to treat

Back 10

slow growing
can be dormant
lipid rich cell wall
infection inside host cell

Front 11

probability of drug resistance

Back 11

1 in 10^6

Front 12

number of bacteria usually present in infection

Back 12

10^8

Front 13

1st line drug for latent TB infection

Back 13

isoniazid

Front 14

isoniazid is bacteristatic or bactericidal

Back 14

bactericidal

Front 15

isoniazid is what kind of drug (metabolically)

Back 15

prodrug: needs to be activated

Front 16

mechanism of resistance to isoniazid

Back 16

decreased activation of drug

Front 17

isoniazid metabolism

Back 17

acetylated and cleared by liver

Front 18

isoniazid is excreted in urine in what form

Back 18

metabolite

Front 19

drug drug interaction considerations with isoniazid

Back 19

inhibits CYP 3A4

Front 20

side effects of isoniazid

Back 20

inhibits neurons and hepatocytes
drug induced hepatitis
peirpheral neuropathy and CNS toxicity

Front 21

most important risk factor for isonizid induced hepatitis

Back 21

age

Front 22

alternative treatment of latent TB infection

Back 22

rifampin

Front 23

why is there no cross resistance between the 1st line drugs

Back 23

all work by different mechanisms

Front 24

bactericidal first line drugs

Back 24

isoniazid
rifampin
pyrazinamide
streptomycin

Front 25

bacteriostatic first line drugs

Back 25

ethambutol

Front 26

which first line drug is not orally effective

Back 26

streptomycin

Front 27

which first line drug is not hepatotoxic

Back 27

streptomycin
ethambutol

Front 28

first line drugs that are hepatotoxic

Back 28

rifampin
isoniazid
pyrazinamide

Front 29

rifampin side effects

Back 29

hepatitis
fllu like syndrome
red fluids

Front 30

pyrazinamide side effects

Back 30

hepatotoxicity
hyperuricemia

Front 31

ethambutol side effects

Back 31

optic neuritis
hyperuricemia

Front 32

streptomycin side effects

Back 32

ototoxicity
nephrotoxicity

Front 33

first line drug that doesnt bind well to human enzymes (selective toxicity)

Back 33

rifampin

Front 34

first line drug that causes ototoxicity

Back 34

streptomycin

Front 35

first line drug where age is most important factor in determining hepatotoxicity

Back 35

isoniazid

Front 36

first line drug with significant interactions with protease
inhibitors and non-nucleoside reverse transcriptase inhibitors NNRTIs

Back 36

rifampin

Front 37

rifampin has what effect on NNRTI and PI blood levels

Back 37

decreases

Front 38

drug used to avoid PI and NNRTI interaction with rifampin

Back 38

rifabutin

Front 39

least effective first line drug

Back 39

ethambutol

Front 40

when is streptomycin indicated for TB treatment

Back 40

life threatening disease
drug-resistant infection

Front 41

recommended initial and continuation therapy for the treatment of
active TB infection in the general population in the absence of isoniazid
resistanc

Back 41

initial (2 mo): INH, RIF, PZA, and ETB
continuation (4 mo): INH, RIF

Front 42

recommended initial and continuation therapy for the treatment of active TB infection in the general population in the presence of isoniazid
resistance

Back 42

initial (6 mo): RIF, PZA, ETB
continuation: none