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4 Cards in this Set
- Front
- Back
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SX of Parkinson's Disease caused by...
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Deterioration of the dopaminergic neurons in the substantia nigra pars compacta, resulting in depletion of dopamine along the nigrostriatal pathway to neurons in autonomic ganglia, basal ganglia & spinal cord causing neuro deficits.
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SX of PD are...
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- muscle tremors,
- slowness of movement in performing daily activities (bradykinesia), - muscle weakness with rigidity, and - alterations in posture and equilibrium |
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What neurotransmitter pathway is affected in PD?
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Dopaminergic pathway (inhibitory neurons) in the substanstia nigra and corpus striatum (neurotransmitter ratio shifts toward decreased DA and increased Ach)
- Increased ACh causes PD sx |
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Drug therapy for PD
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1. Rasagiline or selegiline to slow deterioration of dopaminergic nerve cells
2. Carbidopa-devodopa, ropinirole, pramipexole amantadine or entacapone to enhance dopaminergic activity 3. Anticholinergic agents to inhibit excess cholinergic activity |
