Drugs To Cram

Front 1

Lepirudin
Bivalirudin

Back 1

Directly inhibit thrombin; hirudin derivatives; use for pts with HIT

Front 2

Desmopressin

Back 2

Causes release of vWF from endothelial cells; only 30 min effect; use for mild vWFD

Front 3

Aminocaproic acid

Back 3

Used for thrombolytic overdose (inhibits fibrinolysis)

Front 4

Dipyramidole

Back 4

Blocks TxA2 synthesis

Front 5

ticlopidine

Back 5

Binds ADP receptor- inhibits fibrinogen binding to IIb/IIIa

Toxicity = neutropenia

Front 6

Bortezomib

Back 6

Proteosome inhibitor used to tx multiple myeloma and Waldenstroms

Front 7

Gentuzimab

Back 7

Target for CD33/CD34 for AML

Front 8

Rituximab

Back 8

Target for CD19/20 for NHLs

Front 9

Imatinib

Back 9

anti-bcr-abl antibody to treat philadelphia chromosome in CML

Front 10

Methotrexate

Back 10

Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers

Front 11

5-FU

Back 11

Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!

Front 12

Azothioprine

Back 12

Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG

Front 13

Cytarabine

Back 13

Inhibits DNA polymerase (pyrmidine antagonist)

Front 14

Methotrexate

Back 14

Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers

Front 15

Antimetabolites: purine analogs and pyrimidine analogs

Back 15

Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine

Front 16

5-FU

Back 16

Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!

Front 17

Methotrexate

Back 17

Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers

Front 18

Azothioprine

Back 18

Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG

Front 19

Methotrexate

Back 19

Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers

Front 20

Methotrexate

Back 20

Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers

Front 21

Methotrexate

Back 21

Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers

Front 22

Methotrexate

Back 22

Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers

Front 23

5-FU

Back 23

Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!

Front 24

Cytarabine

Back 24

Inhibits DNA polymerase (pyrmidine antagonist)

Front 25

5-FU

Back 25

Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!

Front 26

Azothioprine

Back 26

Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG

Front 27

5-FU

Back 27

Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!

Front 28

5-FU

Back 28

Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!

Front 29

5-FU

Back 29

Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!

Front 30

Azothioprine

Back 30

Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG

Front 31

Antimetabolites: purine analogs and pyrimidine analogs

Back 31

Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine

Front 32

Cytarabine

Back 32

Inhibits DNA polymerase (pyrmidine antagonist)

Front 33

Azothioprine

Back 33

Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG

Front 34

Cytarabine

Back 34

Inhibits DNA polymerase (pyrmidine antagonist)

Front 35

Azothioprine

Back 35

Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG

Front 36

Azothioprine

Back 36

Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG

Front 37

Antimetabolites: purine analogs and pyrimidine analogs

Back 37

Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine

Front 38

Methotrexate

Back 38

Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers

Front 39

Cytarabine

Back 39

Inhibits DNA polymerase (pyrmidine antagonist)

Front 40

Cytarabine

Back 40

Inhibits DNA polymerase (pyrmidine antagonist)

Front 41

Cytarabine

Back 41

Inhibits DNA polymerase (pyrmidine antagonist)

Front 42

Antimetabolites: purine analogs and pyrimidine analogs

Back 42

Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine

Front 43

5-FU

Back 43

Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!

Front 44

Antimetabolites: purine analogs and pyrimidine analogs

Back 44

Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine

Front 45

Antimetabolites: purine analogs and pyrimidine analogs

Back 45

Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine

Front 46

Antimetabolites: purine analogs and pyrimidine analogs

Back 46

Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine

Front 47

Azothioprine

Back 47

Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG

Front 48

Cytarabine

Back 48

Inhibits DNA polymerase (pyrmidine antagonist)

Front 49

Antimetabolites: purine analogs and pyrimidine analogs

Back 49

Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine