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49 Cards in this Set

  • Front
  • Back
Lepirudin
Bivalirudin
Directly inhibit thrombin; hirudin derivatives; use for pts with HIT
Desmopressin
Causes release of vWF from endothelial cells; only 30 min effect; use for mild vWFD
Aminocaproic acid
Used for thrombolytic overdose (inhibits fibrinolysis)
Dipyramidole
Blocks TxA2 synthesis
ticlopidine
Binds ADP receptor- inhibits fibrinogen binding to IIb/IIIa

Toxicity = neutropenia
Bortezomib
Proteosome inhibitor used to tx multiple myeloma and Waldenstroms
Gentuzimab
Target for CD33/CD34 for AML
Rituximab
Target for CD19/20 for NHLs
Imatinib
anti-bcr-abl antibody to treat philadelphia chromosome in CML
Methotrexate
Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers
5-FU
Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!
Azothioprine
Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG
Cytarabine
Inhibits DNA polymerase (pyrmidine antagonist)
Methotrexate
Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers
Antimetabolites: purine analogs and pyrimidine analogs
Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine
5-FU
Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!
Methotrexate
Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers
Azothioprine
Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG
Methotrexate
Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers
Methotrexate
Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers
Methotrexate
Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers
Methotrexate
Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers
5-FU
Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!
Cytarabine
Inhibits DNA polymerase (pyrmidine antagonist)
5-FU
Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!
Azothioprine
Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG
5-FU
Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!
5-FU
Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!
5-FU
Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!
Azothioprine
Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG
Antimetabolites: purine analogs and pyrimidine analogs
Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine
Cytarabine
Inhibits DNA polymerase (pyrmidine antagonist)
Azothioprine
Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG
Cytarabine
Inhibits DNA polymerase (pyrmidine antagonist)
Azothioprine
Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG
Azothioprine
Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG
Antimetabolites: purine analogs and pyrimidine analogs
Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine
Methotrexate
Inhibits dihydrofolate reductase; leukovorin rescue; can cause macrovesicular change in liver (like alcohol) and oral ulcers
Cytarabine
Inhibits DNA polymerase (pyrmidine antagonist)
Cytarabine
Inhibits DNA polymerase (pyrmidine antagonist)
Cytarabine
Inhibits DNA polymerase (pyrmidine antagonist)
Antimetabolites: purine analogs and pyrimidine analogs
Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine
5-FU
Inhibits thymidylate synthase; thymidine "rescue" since NOT reversible with leukovorin!
Antimetabolites: purine analogs and pyrimidine analogs
Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine
Antimetabolites: purine analogs and pyrimidine analogs
Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine
Antimetabolites: purine analogs and pyrimidine analogs
Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine
Azothioprine
Forms 6-MP
Purine analog activated by HGPRTase

Bone marrow toxicity worsened with allopurinol; if want to use allopurinol, use 6-TG
Cytarabine
Inhibits DNA polymerase (pyrmidine antagonist)
Antimetabolites: purine analogs and pyrimidine analogs
Purine: 6-MP, 6-TP
Pyrimidines: Methotrexate, 5-FU, Cytarabine