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12 Cards in this Set
- Front
- Back
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What does Ca do in the Action Potential?
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Potentiate its length and proportionately effect the strength of contraction
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How does Ca cause contraction in the heart?
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A small amount enters via membrane Ca channel
It binds Ca channels on the SR causing a massive release of Ca = contraction Reuptake is via Ca pump on SR and Ca/Na exchanger |
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What is Adrenaline's effect on the heart and how does it do it?
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Increases Ca stores via G-protein leading to increased activity of membrane Ca channel and SR Ca pump.
Thus when contraction - higher amount of Ca release, stronger contraction |
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What are Glycoside's effect on the heart and how do they do it?
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Block the Ca/Na exchanger, increasing intracellular Ca thus more goes into SR store.
Thus when contraction - higher amount of Ca release, stronger contraction |
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How do Ca Channel blockers effect the heart?
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Decrease Ca, decrease force
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How does smooth muscle differ from cardiac/skeletal muscle?
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Doesn't have troponin or tropomyosin.
Ca bind Calmodulin instead which binds MLCK which phosphorylate myosin, activating it |
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What 8 drug groups can be used to treat Hypertension?
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Decrease CO
Ca channel blockers Beta 1 antagonist Decrease Blood Volume or Resistance: alpha 1 antagonists alpha 2 agonist Diurectics Vasodilators ACE inhibitors Angiotensin II inhibitors |
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Give an example of a Ca Channel Blocker:
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Nimodipine
Amlodipine Mibefradil |
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Give an example of a Vasodilator:
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Hydralazine
Minoxidil Indapamide |
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Give an example of a Beta 1 antagonist:
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Metaprolol
Atenolol |
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Which drugs improve the prognosis of Ischaemica Heart Disease?
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Statins
ACE inhibitors Beta 1 antagonists Aspirin |
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Which drugs improve the symptoms of Ischaemic Heart Disease?
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Nitrates
Beta 1 antagonists Ca Channel Blockers |
