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27 Cards in this Set
- Front
- Back
carbamezapine
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AED - prolongs inactivation of voltage-gated Na+ channels
teratogen Induces CYP3A4 and CYP2C9 SJS and TEN inducer |
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phenytoin
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AED - prolongs inactivation of voltage-gated Na+ channels
teratogen Induces CYP3A4 and CYP2C9 SJS and TEN inducer rapid injection leads to cardiac arhythmias |
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lamotrigine
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AED - prolongs inactivation of voltage-gated Na+ channels
T-type Ca2+ blocker Induces SJS and TEN Induces glucoronidation |
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topiramate
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AED - prolongs inactivation of voltage-gated Na+ channels
Induces CYP3A4 and Inhibits CYP2C9 |
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lacosamide
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AED - prolongs inactivation (SLOW!!!!!!!)of voltage-gated Na+ channels
metabolized by CYP2C9 |
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rufinamide
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AED - prolongs inactivation of voltage-gated Na+ channels
Induces CYP3A4 metabolized by glucoronidation |
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valproic acid
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AED - prolongs inactivation of voltage-gated Na+ channels
Inhibits breakdown of GABA Teratogen Inhibits CYP2C9 |
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zonisamide
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AED - prolongs inactivation of voltage-gated Na+ channels
T-type Ca2+ blocker Metabolized by CYP3A4 |
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What drugs will CYP3A4 inducers affect (carbamezapine, phenytoin, topiramate, rufinamide)
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topiramate
valproic acid lamotrigine tiagabine zonisamide |
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what drugs will CYP2C9 inducers (carbamezapine, phenytoin) or CYP2C9 inhibitors (topiramate, valproic acid) affect
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lacosamide
|
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what AEDs are teratogens
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carbamezapine
phenytoin valproic acid |
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What AEDs are SJS and TEN inducers
|
carbamezapine
phenytoin lamotrigine |
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what drugs are used for tourette's, OCD, ADHD, autism
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Tourette's - domapine antagonist
OCD - SSRI ADHD - dopamine agonist Austim - unknown |
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tolcapone
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Parkinson's
COMT inhibitor |
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entacapone
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Parkinson's
COMT inhibitor |
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Selegeline
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Parkinson's
MAO-B Inhibitor |
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Bromocriptine
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Parkinson's
D2, D1 partial agonist |
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Pergolide
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Parkinson's
D2, D1 partial agonist |
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Ropinirole
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Parkinson's
D2, D3 agonist |
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Pramipexole
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Parkinson's
D2, D3 agonist |
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Levodopa/carbidopa
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Parkinson's
Dopamine precursor |
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Risperidone
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Huntington's
D2 antagonist |
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Tetrabenazine
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Huntington's
Vesicle reuptake blocker |
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For Parkinson's, what are breakdown inhibitors
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COMT - tolcapone, entacapone
MAO-B - selegeline |
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For Parkinson's, what are dopamine agonists
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D2, D1 partial - bromocriptine, pergolide
-CAPONES D2, D3 - ropinerole, pramipexole -OLE |
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For Huntington's, what is D2 antagonist
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risperidone
|
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For Huntington's, what is vesicle reuptake inhibitor
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tetrabenazine
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