Drugs Of Abuse Ii

Front 1

Opiods

Back 1

1. mu agonist
2. has tolerance and non life-threatening physical dependence
3. withdrawal: methadone, buprenorphine
4. dependence: substitution tx = methadone, antagonist tx = naltrexone

Front 2

sedative hypnotics

Back 2

1. barbiturates, ETOH, BZs
2. positive allosteric modulators of GABAa
3. has tolerance and life-threatening physical dependence
4. OD: EtOH/barbiturate - life support, BZs - flumazenil (antagonist)
5. withdrawal: use BZ for all three class withdrawals
6. dependence: BZs - antidepressants, EtOH - disulfiram and naltrexone

Front 3

volatile intoxicants

Back 3

1. solvents (glue, paint) and anesthetics (NO)
2. MoA unknown but likely GABAa
3. cross tolerance w/CNS depressants
4. no physical dependence or w/d because short duration of actoin doesnt allow time to produce sustained dependence, but does have acute W/D syndrome of seizures related to fast onset and remission inducing compensatory stimulant effect
5. OD tx is life support, BZs for convulsions

Front 4

nicotine

Back 4

1. MoA: nicotinic AchR
2. has tolerance and physical dependence as well - mild and diffuse w/d is variable
3. No OD
4. dependence tx: bupropion (atypical antidepressant) and varenicline (partial agonist) - nightmares