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6 Cards in this Set
- Front
- Back
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Ether
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Halothane
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Nitrous oxide
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Etomidate
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IV anaesthetic
Potentiates GABAaR (primarily) -> longer GABAergic IPSP --- Metab faster than thiopental -> less prolonged effects |
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Propofol
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IV anaesthetic
Potentiates GABAaR (primarily) -> longer GABAergic IPSP --- Metab faster than thiopental -> less prolonged effects Used for induction + maintenance of anaesthesia (low post-op nausea/emesis) |
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Thiopental (aka thiopentone)
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Barbituate
V high lipid solubility IV injection -> LOC w/in 10sec -> LOC lasts 5-10mins BUT t1/2 = 9hrs --- Three tissue groups (blood flow/ unit weight): - High: brain, heart, viscera, glands - Low: muscle and skin - V low: fat --- NOTE: recovery from LOC due to REDISTRIBUTION not METABOLISM --- Phases of redistribution: - During injection = high conc in blood -> brain, low in fat - Fast = diffuses out of high flow tissues -> low flow Offset of anaesthetia as thiopental leaves brain - Intermediate = diff out of low flow, still entering fat - Terminal = mostly in fat, some metabolised (t1/2 = 9hrs) --- NOTE: repeating doses -> Cp after fast redistrib EXCEEDS min level for anaesthesia (awaiting distrib into fat + elim), drastic ↑(LOC time) --- One of three drugs used in the lethal injection (US): - Thiopental - ultra-short acting barbituate - Pancuronium - non-depoln muscle relaxant (NMJ) - Potassium chloride - cardiac Vm less (-)ve -> cannot repoln (more NaV inact) |
