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27 Cards in this Set
- Front
- Back
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Which kind of drugs have increased trapping on fetal side?
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Basic drugs
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What happens as drug lipid solubility goes up?
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Increased transfer across placental membrane
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How are drugs classified with risk of teratogens?
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X = know
A-D increasing severity |
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Category A
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Safe
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Category B
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No evidence past 1st trimester
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Category C
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Effects in animals, but not studied in women
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Category D
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Positive evidence of fetal risk, but might be used to save mom
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Category X
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There is evidence of bad effects
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What factors control an organisms susceptibility to teratogens?
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Genotype
Developmental stage of fetus |
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What is teratogensis?
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Effects are dose dependent
Produce malformations |
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Most critical period for fetus?
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3 weeks -7 weeks
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Which drugs do you need to know have teratogenic potential?
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Phenytoin
Anticoagulants Alcohol Methotrexate DES Thalidomide |
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What is the best choice for analgesia during pregnancy?
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Acetaminophen
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NSAIDs do what during pregnancy?
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Increase risk of miscarriage
Increase labor Premature closure of ductus arteriosus |
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What is used to control nausea and vomiting during pregnancy?
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Premesis Rx (Vitamin B6, B12, folic acid, calcium carbonate)
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What should you give in preclamsia?
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Bed rest
Phonobarbital Aspirin |
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What should you do for eclampsia?
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Bed rest
Magnesium sulfate Hydralizine Labetalol |
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Name drugs that has significant impact in lactation
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Chloral hydrate
Choloramphenicol Diazepam Heroin Radioactive Iodine Lithium Methadone Propylthiouracil |
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Which metabolism is more developed in neonates?
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Phase 1 more than Phase 2
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When is adult renal function attained?
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Year 1
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What is the calculation of dose when using age?
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Adult dose X (age / age+12)
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How do you calculate dose based on weight?
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Adult dose x (lbs/150)
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Which form of dose calculation is preferred?
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Surface area from chart
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Growth retardation can be caused by these two drugs
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Amphetamine
Methylphenidate |
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Which drug can effect kids teeth?
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Tetracycline
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Which drug causes Reyes during a viral illness?
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Aspirin
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What can cause kernicturus?
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Competition of drug binding with billirubin to plasma proteins
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