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30 Cards in this Set
- Front
- Back
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cyclosporine MOA
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- binds to CYCLOPHILINS
- complex blocks diff'n & activ'n of T cells by (-) CALCINEURIN - thus, prevents production of IL-2 & its receptor |
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suppresses organ rejection after transplantation
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- cyclosporine
- tacrolimus - azathioprine (kidney) - sirolimus/rapamycin (kidney) |
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uses of cyclosporine
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- suppress organ rejection after transplant
- some autoimmune d/o's |
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predisposes pts to viral infections & lymphomas & is nephrotoxic
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cyclosporine
(nephrotox prevented w/MANNITOL DIURESIS) |
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prevent cyclosporine nephrotoxicity with this
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mannitol diuresis
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tacrolimus MOA
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binds to FK-binding protein→ (-) secr of IL-2 & other cytokines
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uses of azathioprine
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- kidney transplant
- autoimmune d/o's (incl glomerulonephritis & hemolytic anemia) |
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uses of tacrolimus
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potent immunosuppressive used in organ transplants
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tacrolimus toxicity
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- nephrotox
- periph neuropathy - HTN - pleural effusion - hyperglycemia |
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MOA of azathioprine
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- anti-metabolite precursor of 6-MP
- interferes w/metab & synth of nucleic acids - toxic to prolif'ing lymphocytes |
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azathioprine toxicity
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- BM suppression
- active metabolite mercaptopurine is metab'd by XANTHINE OXIDASE - thus, toxic effects ↑ by ALLOPURINOL |
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monoclonal antibody that binds CD3 (epsilon chain) on surface of T cells
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Muromonab-CD3 (OKT3)
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blocks cellular interaction w/CD3 protein responsible for T-cell signal transduction
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Muromonab-CD3 (OKT3)
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uses of Muromonab-CD3 (OKT3)
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immunosuppression after kidney transplant
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Muromonab-CD3 (OKT3) toxicity
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- cytokine release syndrome
- hypersensitivity rxn |
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binds to mTOR
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sirolimus (rapamycin)
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inhibits T cell prolif in response to IL-2
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sirolimus (rapamycin)
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sirolimus (rapamycin) uses
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immunosuppression after kidney transplant
(in combo w/cyclosporine & corticosteroids) |
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sirolimus (rapamycin) toxicity
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("Sir Hits The Lady")
- Hyperlipidemia - Thrombocytopenia - Leukopenia |
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inhibits de novo guanine synthesis & blocks lymphocyte production
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mycophenolate mofetil
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monoclonal antibody w/high affinity for the IL-2 receptor on activated T cells
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Daclizumab
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clinical use of Aldesleukin
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(recombinant cytokine = IL-2)
- renal cell CA - metastatic melanoma |
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clinical use of erythropoetin
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(recombinant cytokine = epoetin)
- anemias (esp in renal failure) - chronic kidney dz - pt undergoing chemo |
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clinical use of filgrastim
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(recombinant cytokine = granulocyte colony-stimulating factor)
recovery of BM |
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clinical use of sargramostim
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(recombinant cytokine = granulocyte-macrophage colony-stimulating factor / GM-CSF)
recovery of BM (after chemo) (IL-3 is similar) |
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clinical use of α-interferon
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- hep B & C
- kaposi's sarcoma - leukemias - malignant melanoma |
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clinical use of β-interferon
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multiple sclerosis
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clinical use of γ-interferon
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chronic granulomatous disease
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clinical use of oprelvekin
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(recombinant cytokine = IL-11)
thrombocytopenia (it stims platelet production in BM) |
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clinical use of thrombopoietin
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thrombocytopenia
(it stims platelet production in BM) |
