Drugs Heme And Resp

Front 1

fuosimide

Back 1

loop diuretic sulfa drug; loops lose calcium; inhib TAL prevent conc of urine
tx: edema, CHF, cirrhosis npehrotic syndrome pulm edema poss HTN hyperCa
SE: otottox hypoK dehyration allergy (sulfa), nephrtisi gout
CI aminoglycosides isotonic sec

Front 2

ethacrynic acid

Back 2

phenoxyacetic acid NOT a sulfanamide; loop diretic
SE: hyperuircemia

oop diuretic sulfa drug; loops lose calcium; inhib TAL prevent conc of urine
tx: edema, CHF, cirrhosis npehrotic syndrome pulm edema poss HTN hyperCa

Front 3

HCT

Back 3

thiazide inhib NaCl reasoption in early distal tubule dec diluting capcity of npehron dec Ca excretion high ELECTRLYTE FLUID out
Tx: good for osteoporosiss renal stones nephrgenic DI, HTN, CHF, idiopathic hypercalciuria
SE: hypokalemia, met alk; hyperuriceia, hyperCa, hyperlipidemia, hyperglycemia, sulfa allergy, hyponatremia

Front 4

spironolactone

Back 4

K sparing diretics, competative aldosterone Rc antag in cT

hyperaldosteronism delpitetion CHF dec mortality
SE: hyperkalemia arrhythmias endocrine effects w/ aldost antag (gynecomastia antiandrogen effects

Front 5

eplerenone

Back 5

K sparing diretics, competative aldosterone Rc antag in cT

hyperaldosteronism delpitetion CHF dec mortality
SE: hyperkalemia arrhythmias endocrine effects w/ aldost antag (gynecomastia antiandrogen effects

Front 6

triamterene

Back 6

CT but block Na channels in CCT
tx: acnes PCOS hyperaldosteronism delpitetion CHF dec mortality
SE: hyperkalemia arrhythmias endocrine effects w/ aldost antag (gynecomastia antiandrogen effects

Front 7

amiloride

Back 7

CT but block Na channels in CCT
tx: acnes PCOS hyperaldosteronism delpitetion CHF dec mortality
SE: hyperkalemia arrhythmias endocrine effects w/ aldost antag (gynecomastia antiandrogen effects

Front 8

mannitol

Back 8

osmotic diruetic at PT inc tubular fluid osm inc urine flow
tx: shock drug overdose
inc IC/intraocular pressure gluacoma in emergency
SE: pulm edema dehydration
CI anuria CHF inc serum Na and osm b/c getting rid of a lot of water

Front 9

acetazolamide

Back 9

carbonic anhydrase inhib self liited Na HCO3 diuresis and redction in totacl body HCO3 stores
tx: glaucoma, urinary alk, emt alk, alt sickness
SE: hyperCl, met aicdosis, neuropathy NH3 tox, sulfa allergy, ACIDazolamide causes ACIDosis

Front 10

2 renal drugs causing acidemia

Back 10

carbonic anhydrase inhib and K spareres

Front 11

2 drugs that causing alkalemia

Back 11

loop and thiazides

Front 12

ACEi

Back 12

pril; prevent iac of bradykinin VD;
tx: HTN, CHF diabetic renal disease dec proteinuria inc Cr
SE; cough angioedema PREVENTS proteinuria, taste hyp0tension, preg (renal damage); rash; inc renin lower AT2 hyperkalemia
CI: b/l renal artery stensosis
CAPTOPRIL**

Front 13

cyclosporine

Back 13

cyclophilins diff and activaiton of T cells inhib calcineurin prev prod of IL-2 suppress organ rejection after trnasplant AI disroders predispose pts to viral infection and lymphoma nephrotoxic
mannitol diresis prevents

Front 14

tacrolimus

Back 14

acute rejection sim to cyclosproine binds FKBP inhib secretion of IL-2 potent immunosupp used in organ transplant
SE: nephrotox peripheral neuropahty HTN pelural effusion hyeprglycemia topical for eczema

Front 15

sirolimus

Back 15

binds FKBP inhib mTPR rapamycin inhib t cell prod dec IL2 immunosupp after kidney transplant w/ cyclosporin and corticosteorids
SE: hyeprlipidemai, TP leukopenia
SLe npehrtisi transplants liver kdiney

Front 16

daclizumab

Back 16

monoclonal Ab high aff for IL-2 act on T cells prevent acute rejection

Front 17

azathioprine

Back 17

antimet of 6MP interferes w/ metab and syn of nucleic acids toxic to porlif lymphocytes kidney transplant AI disorders GN hemolytic anmiea SE: BM suppresion active metab of MP xanthin oxidasre in toxic by allopurinal

Front 18

muromonab

Back 18

CD3 OKT3 monoclonal Ab bindns CD3 epsilon chain on T cells blocks cellular inx w/ CD3 kidney transplatn prevents acut etrasnplant rejection
SE: cytokine release syndorme HS

Front 19

thalidomide

Back 19

immunosupp SLe organ trasplant antiagniogenic TNF a
SE: phoceelimia (flapper limpd eformity in preg)

Front 20

heparin

Back 20

AT# inhib thormbin heaprin works there dec htormbin and Xa short HL immed anticoag for pulm embolsim troke acut ecoronary syndrome MI DVT preg (not crossplacenta) follow PTT
SE: bleed TP (HIT) osteoprorosis drug durg intx rapid rev (antidote protamine sulfate )

Front 21

enoxaparin

Back 21

LMWH more Xa better F 2-4 times long HL sub Q no need to monitor labs not easiliy rev; large anionic acidic polymer parenteral IV/SC in blood rapid AT3 dec 2a and Xa acute inhib coag invitro

Front 22

HIT

Back 22

heaprin binds to plt factor 4 antibody prod binds to act plts leadin to their clearnac eTP hypercoag state treat w/ levirudine bivalirudin and warfarin

Front 23

lepirudin

Back 23

hirudine deriates inhib thormbin alt ot heaprin for anticoag pts w/ HIT

Front 24

bivalirudine

Back 24

hirudine deriates inhib thormbin alt ot heaprin for anticoag pts w/ HIT

Front 25

warfarin

Back 25

coumadin interferesw / morman syn AND gamma-carboxy of vit K; met by P45 extrinsic inc PT long HL
Tx: chornic anticoag postratic herat vlave a fib DVt PE gentic hyeprcoag
NOT USED IN PREG follow PT/INR
SE: bleed teratogenic skin/tissue necrosis drug drug itnx; reverse give vit K and FFP small lipid soluble moleculs oral acts at liver slow limited by HL of lcotting factors impaires syn of vit K, chronic no inhib coag in vitro msut give heparin when first strat b/c warfarin inhib C/S so first hypercoag

Front 26

aspirin ASA

Back 26

acetylates irr inhib COx 1/2 prevent conversion of AA to TXA2 inc BT no effect on PT/PTT anitpyretic analgesis antiinflamm antplt
SE: gasrric ulceration bleeding hyperventilation REye sydnrome tinnitus

Front 27

ticlopidine

Back 27

neutorpeniai
nhib ADPinduced expression of Gp2b/3a inhib agg irrev block ADP Rc inhib fibrogen bidning
tx: acute coronary sydnroem coronary stenting dec recurrence of stroke

Front 28

clopidogrel

Back 28

inhib ADPinduced expression of Gp2b/3a inhib agg irrev block ADP Rc inhib fibrogen bidning
tx: acute coronary sydnroem coronary stenting dec recurrence of stroke

Front 29

abciximab

Back 29

inhib Gp2b/3a directly mab act plts prevent agg
tx: acute coronary syndrome not ST seg MI percut trnaluminal coronary angiopaslty
SE: bleed TP

Front 30

eftibifitide

Back 30

inhib Gp2b/3a directly mab act plts prevent agg
tx: acute coronary syndrome not ST seg MI percut trnaluminal coronary angiopaslty
SE: bleed TP

Front 31

streptokinase

Back 31

direct indirectly aid conversion of palsminogen to paslmin cleavs fibirn clots inc PT/PTT no BT
Tx: use ST elevation early MI early sichemic attack storke 3 hrs
SE: bleeding CI in pts w/ active bleed,hx of IC bleed recent surgery bleeding diathesis severe HTN treat toxicty w/ aminocaproic acid inhib of fibrolysis

Front 32

urokinase

Back 32

tPAdirect indirectly aid conversion of palsminogen to paslmin cleavs fibirn clots inc PT/PTT no BT
Tx: use ST elevation early MI early sichemic attack storke 3 hrs
SE: bleeding CI in pts w/ active bleed,hx of IC bleed recent surgery bleeding diathesis severe HTN treat toxicty w/ aminocaproic acid inhib of fibrolysis

Front 33

altepalse

Back 33

direct indirectly aid conversion of palsminogen to paslmin cleavs fibirn clots inc PT/PTT no BT
Tx: use ST elevation early MI early sichemic attack storke 3 hrs
SE: bleeding CI in pts w/ active bleed,hx of IC bleed recent surgery bleeding diathesis severe HTN treat toxicty w/ aminocaproic acid inhib of fibrolysis

Front 34

antistreplase

Back 34

direct indirectly aid conversion of palsminogen to paslmin cleavs fibirn clots inc PT/PTT no BT
Tx: use ST elevation early MI early sichemic attack storke 3 hrs
SE: bleeding CI in pts w/ active bleed,hx of IC bleed recent surgery bleeding diathesis severe HTN treat toxicty w/ aminocaproic acid inhib of fibrolysis