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5 Cards in this Set
- Front
- Back
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Digoxin
class/MOA? uses? adverse? contra? |
-Cardiac glycosides (glycone ring required), inhibits Na/K ATPase pump (inc intracellular Ca)
-acute + chronic systolic HF, Atrial flutter, fibrillation, nodal tachy (depressant effect on AV conduction) -"digitalis delirium", dose dependent small therapeutic index, arrhythmias, visual green halos -WPW, R-HF, amyloid/hypertrophic cardiomyopathy, sick sinus syndrome |
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Dopamine
class/MOA? uses? |
-low= DI vasodilator, med= B1, B2, NE release +inotropic, high= a1, D2, inc HR, HTN, N/V
-acute decompensated HF, cardiogenic/distributive shock, when there is poor renal perfusion |
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Dobutamine
MOA? Adverse? |
-selective for B1, high= B2, a1, increases coronary perfusion, peripherally dilates
-cardiac arrhythmia, anginal pain, HTN, GI system |
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Milrinone
class/MOA? uses? Adverse? |
-phosphodiesterase inhibitor (isoenzyme 3 which inactivates cAMP), increase cAMP leads to inc Ca
-"inodilator", peripheral vasodilation, acute decompensated HF, cardiogenic shock, pts w/ B-blockers -dose related hypotension, V-arr, thrombocytopenia (don't give chronically) |
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Nesiritide
class/MOA? uses? adverse? |
-Atrial natriuretic peptide, activates guanylyl cylcase (inc cAMP synthesis)
-art/venous dilation, inc diuresis for pts with acute decompensated HF -excessive hypotension, renal failure |
