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12 Cards in this Set
- Front
- Back
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drugs that are used for chronic HF? |
Diuretics, ACE inhibitors, ARBs, angiotensin receptors-neprilysin inhibition (LCZ696), aldosterone antagonists, If channel blockers, beta-blockers, digoxin |
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Angiotensin receptor neprilysin inhibitors? |
Sacubitril/ valsartan |
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MOA of angiotensin receptor neprilysin inhibitor? |
Enhances the protective neurohormonal system of heart ( natriutic peptide system). Suppresses the harmful system (the RASS) |
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What are the beta-blockers taht are preferred for HF? |
Bisoprolol, mataprolol, carvedilol, nebivolol. |
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Whats the MOA of digoxin? |
Inhibits the Na/K ATPase (pump). Causes accumulation of intacellular Na and increases intracellular Ca concentrations via reduced Na/Ca exchange. This rise the Ca intracellularly which accounts for the positive inotropic effect of digoxin. |
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Adverse effects of digoxin? |
GI symptoms, bradycardia, cardiac arrhythmias, heart block, altered colour vision (xanthopsia) |
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Drugs used for acute HF? |
-Inotropes (dopamine, dobutamine, phosphodiesterase inhibitors) -nesiritide (BNP) |
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MOA of dopamine? |
It shortly support the circulation. It causes vasodilation by: stimulating dopaminergic receptors (causing cyclic AMP-dependent relaxation), increase renal blood flow |
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Whats the MOA of Phosphodiesterase inhinbitors? |
Decrease the hydrolysis of cAMP. cAMP increase which cause rise in intracellular Ca and increase cardiac contractility. |
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What Milrinone does? Whats the adverse effects? |
Vasodilation > decreased preload and afterload. -dose-limiting adverse effects: tachycardia, arrythmias, hypotenstion. |
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Whats the MOA of nesiritide? |
Its an agonist of natriuretic peptide receptors> stimulate soluble guanylate cyclase and increase vascular levels of cGMP. cGMP relaxes arteries and veins. |
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Major side effect of nesiritides ? |
Prolonged hypotension. |
