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30 Cards in this Set
- Front
- Back
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theophylline
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no age related decrease in bioavailability
decreased clearance by cyp 1A2 |
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digoxin
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delay to peak because of decreased absorption
decreased loading dose needed because bound to muscle and TBW decreased decreased renal clearance |
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ketoconazole, itraconazole
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decreased absorbtion because of decreased gastric acid
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FeSO4
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decreased absorption because of decreased gastric acid
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Transdermal Fentanyl
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delayed plasma doubling time because of decreased acid
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benzos
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increased half life because of increased body fat
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ethanol
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increased concentration because its water soluble and TBW decreased
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lidocaine
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increased binding and accumulation because of increased alpha-1 acid glycoprotein
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propranolol
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increased binding and accumulation because of increased alpha-1 acid glycoprotein
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imipramine
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increased binding and accumulation because of increased alpha-1 acid glycoprotein
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NSAIDS
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possible toxicity because of increased drug free fraction due to decreased albumin
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valporoate
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possible toxicity because of increased drug free fraction due to decreased albumin
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warfarin
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possible toxicity because of increased drug free fraction due to decreased albumin
warfarin sensitivity decreases with liver mass |
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phenytoin
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possible toxicity because of increased drug free fraction due to decreased albumin
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labetalol, propranolol, verapamil
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decreased first pass effect because of decreased liver perfusion
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aminoglycosides
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decreased renal clearance and low therapeutic index because of decreasing renal clearance
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procainamide
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decreased renal clearance and low therapeutic index because of decreasing renal clearance
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vancomycin
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decreased renal clearance and low therapeutic index because of decreasing renal clearance
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lithium
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decreased renal clearance and low therapeutic index because of decreasing renal clearance
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metronidazole
ticarcillin +- clavulanate oral erythromycin nafcillin/methacillin/ampicillin |
high sodium load affects them
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beta blockers and agonists
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decreased response
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anxiolytics
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increased sensitivity
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hypnotics
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increased sensitivity
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diuretics
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monitor it carefully
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ACE-i
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monitor renal function and K+
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chlorpropamide
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avoid
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anticholinergics
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avoid
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barbiturates
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avoid
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meperidine
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avoid
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morphine
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increased sensitivity among the elderly
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