Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
|
Fluoxetine
|
Selective 5-HT reuptake inhibitor
Used as an antidepressant |
|
|
Ondansetron
|
5-HT3 antagonist
Anti - emetic |
|
|
Phenylephrine
|
Alpha1 agonist
Nasal decongestant |
|
|
Prazosin
|
Alpha 1 antagonist
Treats hypertension |
|
|
Atenolol
|
Beta 1 antagonist
Treats hypertension |
|
|
Salbutamol
|
Beta 2 agonist
Treats Asthma and obstructive lung disease |
|
|
Diazepam
|
GABAa agonist
Treats anxiety Not as potent because only effects one specific subset of GABA receptors so not useful for epilepsy |
|
|
Carbachol
|
Cholinergic agonist (just like ACh)
|
|
|
Histamine actions on H1
|
Gq - Calcium - bronchoconstrict.
Anaphylaxis Broken down by hist. methyl transferase |
|
|
Iso>A>>NorA on B2 receptors
|
Gs - cAMP - shuts L type calc channels
increase MLCP hyperpolarises smooth muscle inhibits contraction |
|
|
Aminophylline/Theophylline
|
Xanthine Alkaloid;
1.competitive phosphodiesterase inhibitor so increases B2 effect - bronchodilate 2.adenosine receptor antagonist - final result=bronchodilation :) |
|
|
Hyoscine
|
competitive muscarinic antagonist
|
|
|
mepyrimine
|
H1 receptor antagonist
|
|
|
What acts to contract rat uterus
|
alpha1, Oxytocin, 5-HT
all Gq cascades |
|
|
what acts to dilate rat uterus?
|
Beta 2 stimulation
Gs cAMP, arinase phosphorylate and turns off MLCK |
|
|
how can ACh vasodilate? and why doesnt this happen in parasympathetic output?
|
M3 on vascular ENDOTHELIAL cells, Gq - Calcium increased - activates NOS - so NO produced.
diffuses to SMOOTH MUSC cell, activate guanylyl cyclase -cGMP activates PKG - phosphorylates MLCP dephosphorylation of light chain. No parasympathetic innerve of blood vessels. |
|
|
Physostigmine?
|
inhibit AChE, increase ACh effect.
|
