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48 Cards in this Set
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- 3rd side (hint)
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Class CI for HMG-CoA red inhib
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Active/persistent liver disease
Pregnancy category X Precaution - rhabdo, baseline liver tests |
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Statin Class Drug interactions
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inc myopathy risk w/ gemfibrozil, erythromycin, nicotinic acid
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which 2 statins are CI with itraconazole?
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Mevacor and Zocor
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Lopid dose, counseling
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gemfibrozil, 600mg bid 30min AC!
CI: hepatic/severe renal disease, pre-existing gall bladder disease |
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Tricor Dose, counseling, CI
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Fenofibrate 48-145 mg/d
same CI as Lopid |
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Lovaza dose, indications
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omega-3-acid ethyl esters 4 caps/day or 2 caps bid belching! mainly TG lowering
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Welchol, dose, counseling
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colesevelam 6 tabs/day or 3 tabs bid
AE: constipation! note: drink lots of water |
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Niaspan
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500-2000mg q hs w/food of niacin
FLUSHING PC: diabetes and gout |
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Zetia
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10mg/day w/o regard to meals
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Diuretics: class CI
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anuria, severe electrolyte depletion
increases uric acid crystals in gout AE:dry mouth Give in AM with food or milk avoid laxative use |
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Bumex CHF dosing
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0.5-4mg/day up to 10mg
bumetanide |
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Torsemide CHF vs. HTN
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20-200mg/day for CHF vs
10-200mg/day HTN |
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Hydrochlorothiazide
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12.5-50mg/day
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Indapamide
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Lozol
CHF 2.5-5mg/day HTN 1.25-2.5mg/day |
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Zaroxolyn
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metolazone
2.5-20mg/day CHF/renal dys |
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aldactone Spironolactone
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edema 25-200mg/d vs
HTN 50-100mg/d |
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Inspra
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Eplerenone
HTN/CHF post MI 50mg/day titration CI! K>5.5, CrCl<30, 3A4 inhibitors, Hyperkalemia |
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Dyazide vs. maxzide
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same drugs 1-2 caps/day vs. 1 tab/day
watch for use with other K sparing |
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KCl
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16-80mEq/day full glass of water and a meal to decrease stomach upset
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Plavix and Ticlid
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Active bleeding (GI bleed, peptic ulcer, others)
NSAID inc bleed risk |
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Ticlopidine
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Ticlid 250mg bid!
AE: neutropenia, thrombocytopenia CI: blood dyscrasias irreversible effect on platelets, like plavix |
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Persantine
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dipyridamole
100mg qid~! AE: hypotension worse in elderly co-admin with warfarin/ASA |
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Aggrenox
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dipyridamole and ASA
1 bid subtherapeutic dose of dipyrid?? |
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Counseling on intermittent claudication drugs
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no immediate response up to 8-12 weeks
subjective monitoring - distance w/o pain |
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Pentoxifylline
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400mg tid
Trental hemorheologic inc theo concentrations |
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Cilostazol
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Pletal
100mg bid CI:HEART FAILURE! 3A4 substrate |
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Warfarin
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Coumadin
1, 2, 2.5, 3, 4, 5, 6 7.5, 10mg |
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Hytrin
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Terazosin
additive hypo 1st dose @ night / lowest dose get up slowly |
HTN, BPH: 1-5mg/day
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Cardura XL
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doxazosin
BPH only! 4 mg/day peak 8-9 hours insoluble shell in stool |
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Cardura
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doxazosin
HTN/BPH: 1-16mg/day |
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Minipress
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Prazosin
HTN: 2-5mg tid! start low |
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Apresoline
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hydralazine
HTN: 10-50mg qid long term = SLE! arterial vasodialator |
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Catapres
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clonidine
HTN: 0.1-0.4 bid! TTS for HTN: 0.1mg patch q 7 days do not stop or skip doses |
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Dihydropyridine notes
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Class precaution: reflex tachy due to vasodialation, potential to inc angina
Class AE: lower-extremity edema, orthostatic effects |
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non-dihydropyridine notes
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Class CI: sick sinus, >1st degree heart block, SBP<90mmHg
PREcaution:CHF cause bradycardia constipation |
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Procardia
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nifedipine - interacts w/3A4 inhibs
HTN: 30-90mg/day XL Angina: 30-180mg/day XL |
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Plendil
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Felodipine
HTN: 2.5-20mg/d AE: gingival hyperPLASIA counsel good dental stuff |
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Norvasc
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amlodipine
HTN: 2.5-10mg/d 10 for angina long t1/2 |
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amlodipine and benazepril
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Lotrel
HTN: 1 cap daily many strengths |
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diltiazem
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Cardizem/CD
Ang proph: 30mg qid! before meal/bed HTN: 120-360mg/d empty stomach! |
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Dilacor XR
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Diltiazem
HTN: 120-540 mg/d empty stomach |
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Isoptin/SR
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Verapamil
SR for HTN: 120-240mg qd or bid! reg for ang: 80-160mg tid constipation! |
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Nitrates class contraindications
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concomitant use w/viagra
precaution: tolerance! CCB: additive hypotension headache up to 50% nitrate free interval |
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isosorbide dinitrate
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angina proph: 40mg tid!
SR: 40mg bid! 7am/12pm/5pm vs. 8am/2pm no brand |
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imdur
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isosorbide mononitrate
angina proph: 30-240mg/day split but swallow whole |
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Lanoxin
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digoxin
0.125-0.25mg/day IX: diuretics, amio, macrolides anorexia, halos CHF or afib/flutter |
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cordarone or pacerone
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amiodarone
atrial and ventricular arrhythmias 200-400mg/day t1/2 50 days serious INR raiser, pulmonary fibrosis |
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When can you not initiate beta blockers?
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during shock
or decompensated CHF (SBP<90, HR<60) when d/c'ing beta blockers, titrate over 1-2 weeks |
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