Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
32 Cards in this Set
- Front
- Back
|
Commonalities model of Addiction
|
Mood alteration is a common need for all individuals and occurs through drugs or hedonic activities
Coping response to stress |
|
|
Alexander's model of addiction
|
Prevalence of addiction is a response to living in a global world
|
|
|
Satiation
|
Motivation to shut down responses to internal and external stimulation
|
|
|
Arousal
|
Desire to feel powerful in the environment
|
|
|
Fantasy
|
Desired way of dealing with the world, dreamlike thoughts, mystical experience
|
|
|
Robinson and Berridge Model of Addiction
|
Addiction is neurological and psychological
learning and memory system can trigger a dopamine surge |
|
|
Salient
|
Grabs attention
|
|
|
Beneficial Addiction
|
Accomplishes positive social ends
|
|
|
Centrifugal Addiction
|
Pushes all other events to the periphery of life
|
|
|
Psychoactive drug
|
chemical substance which alters feelings, thoughts, perceptions or behaviours
|
|
|
Potency
|
Amount of dose that is necessary to get its maximum effect
|
|
|
Efficacy
|
Amount of effect relative to the maximum possible effect
|
|
|
ED50
|
Effective dose where 50% of participants will respond
|
|
|
LD50
|
Lethal dose where 50% will die
|
|
|
Therapeutic index
|
LD50:ED50
|
|
|
Margin of Safety
|
LD1:ED99
|
|
|
Absorption
|
processes and mechanisms by which drugs pass from the external world into the bloodstream
|
|
|
half-life
|
time taken for half the molecules of the drug to leave the body
|
|
|
First Line Therapy
|
Treatment recommended for the initial treatment of a disease
|
|
|
First pass metabolism
|
Metabolism in the liver when first going through the bloodstream
|
|
|
P450 Enzyme Family
|
Metabolizes toxic substances in liver
|
|
|
7steps of synaptic transmission
|
Synthesis
Transport Storage Release Reuptake Retrograde transport Recycling |
|
|
GABA
|
Inhibitory transmitter
40% of CNS low GABA causes convulsions |
|
|
Glutamate
|
Excitatory transmitter
synthesized form glucose Alcohol withdrawal due to glutamate |
|
|
Acetylcholine
|
Associated with memory, attention, learning
Nicotine is agonist |
|
|
Norepinephrine
|
Autonomic arousal
Stimulants raise NE Associated with mood, panic |
|
|
Serotonin
|
Widespread distribution in CNS and PNS
SSRI's to combat:depression, eating disorders and obsessive compulsive disorders |
|
|
Dopamine
|
Reward transmitter
|
|
|
Mesolimbic
|
Pathway for drugs
|
|
|
Niagra striatal
|
Pathway for movement
|
|
|
Mesocortical
|
Pathway for thinking (schizophrenia results from malfunction)
|
|
|
Enkephalin
|
morphine-like substances found in midbrain structures and spinal cord
|
