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14 Cards in this Set
- Front
- Back
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Warfarin
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Coumarins
Oral anticoagulant Vitamin K antagonist Warfarin prevents the chemical reduction of vit K (which is necessary for its action as a co-factor Takes time to develop action Side effect: Haemorrhage |
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Rivaroxaban
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Oral Anti-coagulant drugs
Prevent clots Side effects: haemorrhage and feeling sick |
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Heparin
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Injectable anticoagulants
Quick and immediate Acts on antithrombin III |
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Hirudins
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Direct thrombin inhibitors
Peptides that bind reversibly to fibrin-binding site and catalytic sites of thrombin --> inhibit this factor Uses: thromboembolic disease in patients who develop Heparin-induced t thrombocytopenia type II while on chronic heparin treatment |
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Lepirudin
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Direct thrombin inhibitors
Injection |
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Menadiol sodium diphosphate
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given by I.M/I.V. – treat acquired clotting defects e.g. liver disease, vit K deficiency or ingestion of anticoagulants and natural vit K
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Aspirin
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Antiplatelet drugs
inhibits cyclooxygenase (COX) which blocks TXA2 synthesis --> no further aggregation of platelets |
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Clopidogrel
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Antiplatelet drugs
inhibits P2Y12 purinergic receptors. Inhibits ADP-induced platelet aggregation |
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Abiciximab
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Antiplatelet drugs
glycoprotein IIb/IIIa receptor antagonists |
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Tirofibam
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Antiplatelet drugs
glycoprotein IIb/IIIa receptor antagonists |
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Dipyridimole
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Antiplatelet drugs
inhibits PDE and adenosine uptake |
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Epoprostenol
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Antiplatelet drugs
PGI2 analogue |
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Streptokinase
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Fibrinolytic agents
Non enzymic protein Act indirectly by forming a stable complex with plasminogen which gains enzymic activity due to conformational change |
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Altepase
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Tissue Plasminogen Activators (TPA)
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