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20 Cards in this Set
- Front
- Back
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In the somatic motor system, acetylcholine is released at the motor end plate and stimulates which receptors?
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Nicotinic recptor
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Lignocaine is used as a....
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local anaesthetic
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What is the action of lignocaine in the blockade of transmission at the neuromuscular junction?
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Blocks nerve action potential
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Hemicholinium and triethylcholine prevents the uptake of?
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choline
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What is the action of vesamicol in the blockade of transmission at the neuromuscular junction?
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prevents acetylcholine uptake into vesicles
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Mg2+ and aminoglycoside anibacterial drugs such as s_______ and n_______ inhibits Ca2+ entry
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streptomycin and neomycin
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Atraxotoxin and b-bungarotoxin inhibits the release of?
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Acetylcholine or deplete vesicles
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a-bungarotoxin blocks?
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postsynaptic nicotinic receptros
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What are the symptoms caused by botulinum toxin?
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Dry mouth, blurred vission, difficulty swallowing and respiratory paralysis
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Botulinum toxin contains 2 subunit what does each one do?
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One binds to membrane of cholinergic neurone whilst the other subunit contains A-G that are peptidases, which breaks down proteins involved in exocytosis
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How many subunits does the nicotinic receptor compose of?
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5
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Tubocurarine is a ___-___________ agent
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non-depolarising
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Tubocurarine and pancuronium has a (short/intermediate/long) duration
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Long duration 1-2 hours
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Atracurium and vecuronium has a (short/intermediate/long) duration
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intermediate duration 30 - 40 mins
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Mivacurium has a (short/intermediate/long) duration
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Short duration 15 mins
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Increasing concentrations of non-depolarising neuromuscular blockade diminishes the amplitude of? (EPP)
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End-plate potential
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Fall of EPP to below 70% of its initial value causes a failure to....
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initiate propagated muscle action potential
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Neostigimine or pyridostigmine are ______________ drug
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anticholinesterase drug
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Decamethonium and suxamethonium acts as a______at nicotinic receptors producing a persistent depolarisation
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agonists
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With prolonged administration of drugs, this may block neurotransmission which is due to receptor d_________
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desensitisation (phase 2)
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