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52 Cards in this Set
- Front
- Back
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halothane (fluothane)
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mac:0.75
mac with n20: 0.29 |
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potency of halothane
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OG:224
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solubility of halothane
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BG: 2.3
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vapor pressure of halothane
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244 mmhg
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metabolism of halothane
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20%
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comments about halothane
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most potent, most lipid soluble, hepatitis, heart arrythmia,halogenated hydrocarbon, gabamimetic, nonflammable,inc icp, dec cmro2, mh trigger, dec bp, co, sensitizes heart to catecholamine->dysrhthmia, slow sa node, best bronchodilator!, inc hepatitis with repeated expostues, compound A, dont give ccb and bb (myocardial depressant),max epi (1:100000 10 ml/10 min (0.1 mg) or 30 ml/hr (0.3)
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contraindications with halothane
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liver dx,obgyn,incranial mass (increase icp), aminophylline-arrythmia, cardiac disease
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mac of isoflurane (florane)
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1.15
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isoflurane mac with 70% n20
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0.36
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isoflurane potency
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og 99
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isoflurane solubility
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bg:1.4
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vp isoflurane
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240
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metabolism of isoflurane
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<1 (trace)
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comments isoflurane
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great for neuro pt, coronary steal (avoid in CAD), VASODILATION, bronchodilator like all except n20,
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enflurane mac
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1.63
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enflurane mac with n20
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0.6
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enflurane potency
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og 97
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enflurane bg
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1.9
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vp of enflurane
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172
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metabolism of enflurane
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2-3%
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enflurane comments
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no neuro,sz,.renal pt
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sevoflurane(ultane) mac
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2
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onset of sevo
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7-10 min
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sevo mac with n2o
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0.60
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og of sevo
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50
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bg of sevo
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0.60
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vp of sevo
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170
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metabolism of sevo
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5-7%
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desflurane(suprane) mac
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5.8
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desflurane ogs
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18.7
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desflurane bgs`
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0.42
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desflurane vp
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669
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boiling point desflurane
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23.5 C
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comments on desflurane
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quick on and off, expensive, renal toxic,irritant, sns stimulation->transient tachycardia and htn, carbon monoxide with sodalyme>baralyme. minimize carbon monoxide risk by changing dried absorbant or use calcium hydroxide, doesnt increase coronary blood flow like iso! emergence delirium in peds
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desflurane with 70% n20
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1.8
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onset of des,iso,halothane,n20
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1-2 min
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n20 bgs
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0.47
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n20 mac
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105
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n20 ogs
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1.4 most potent
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contraindication in n20
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abdominal bowel obstruction, bleb on xray, vae,pneumothorax, ear, eye surgery , cuff , preg, ( b12 inhibition/methionine synthesase deficency)->immunosuppression, increase icp!
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n20 boiling point
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-88 C
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comments on n20-
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insoluble ,faster induction, teragenic, inhibit methionine need for dna synthesis, immune suppression,insoluble agents (n20) are taken up by blood less (desirable) avidly than soluble agents ( halothane). alveolar conc of n20 rises faster than halothane and induction is faster. increase ponv,inc crmo2, 35x more soluble than n2 in blood so will expand in air cavities. diffusion hypoxia, faciltates absorption of 2nd gas wth slow onset, INORGANIC compound, equal to 15 mg morphine, potentiate opioid,no resp or bronchodilation, bone marrow suppression, combusion,no prego! pulmonary vascular constriction,no bronchodilation or resp. depression
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mac awake:
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0.3-0.5 mac
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mac 95%
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1.3
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ogs vs bgs
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the greater the bgs the greater the anesteic solubility that goes to blood ( pulm circulation), alveolar partial pressure rises more slowly and induction is prolonged
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mac bar(block autonomic response)
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1.5 mac
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how do you increase speed of induction
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increase concentration of volatile agent, high flows, and increase mv. increase co slows the induction!
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mac in children
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children require higher mac ( infant at term to six month)
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factors increase mac
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hyperthermia, hyper na, increase levels of cns,excitatory transmitters (cocaine), chonic alcohol
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decrease mac
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hypothermia, hypona,preg, inc age, acute alcohol,alpha agonist (clonidine),cns depressant
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sevo comments
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no renal (compound A), peds -sz but are good for peds, >2 LFGF, direct myocardial depression more than iso/des, no coronary steal,inc ponv
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sevo generic
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ultane
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