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130 Cards in this Set
- Front
- Back
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etidronate
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bisphosphonates inhib osteclasts, less form and resorption of hydroxyapetitie tx malignancy assoc hypercalcemia, paget's postmenopausal osteoperosis
SE erosiveesphagitis, nasea diarrhea osteonecrosis |
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alendroante
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bisphosphonates inhib osteclasts, less form and resorption of hydroxyapetitie tx malignancy assoc hypercalcemia, paget's postmenopausal osteoperosis
SE erosiveesphagitis, nasea diarrhea osteonecrosis |
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risedronate
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bisphosphonates inhib osteclasts, less form and resorption of hydroxyapetitie tx malignancy assoc hypercalcemia, paget's postmenopausal osteoperosis
SE erosiveesphagitis, nasea diarrhea osteonecrosis |
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zoledronate
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IV form NO esophagitis
bisphosphonates inhib osteclasts, less form and resorption of hydroxyapetitie tx malignancy assoc hypercalcemia, paget's postmenopausal osteoperosis SE nasea diarrhea osteonecrosis |
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apmidronate
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bisphosphonates inhib osteclasts, less form and resorption of hydroxyapetitie tx malignancy assoc hypercalcemia, paget's postmenopausal osteoperosis
SE erosiveesphagitis, nasea diarrhea osteonecrosis |
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colchicine
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acute gout plus NSAIDS
MT drug depolymerization, impair leukocyte chemotaxis and degran SE: GI indomethacin less toxic reduce resonse to MSU inflamm |
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probenecid
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chronic gout
inhib reabsorption of uric acid in PCT increase excretion sulfinpyrazone is very similar ***increases effects of cephalosporins, PCN sulfonamides |
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allopurinol
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chronic gout NOT acute
xanthin oxidase inhib INC xanthin decreast uric acid (dec production of uric acid) leukemia prophylaxis azathioprine 6MP do not give salicylaste unless very high doses |
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asprin
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inhib COX dec TX/PG low dose (inhib plt 3-5 days), antipyretic, analgesic; antiinflammatory (gout) at high doses; SE: gastric upset can lead to ARF interstitial nephritis upper GI bleed and Reye syndrome w/ virla infeciton flu/VZV
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ibuprofen
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NSAID inhib COX1/2 block PG, antipyretic analgesic antiinflam
SE: renal damage fluid rtn aplstic anemia GI ulcers |
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naproxen
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NSAID inhib COX1/2 block PG, antipyretic analgesic antiinflam
SE: renal damage fluid rtn aplstic anemia GI ulcers ***least SE |
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indomethacin
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NSAID inhib COX1/2 block PG, antipyretic analgesic antiinflam
SE: renal damage fluid rtn aplstic anemia GI ulcers **strongest closes PDA |
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ketorolac
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NSAID inhib COX1/2 block PG, antipyretic analgesic antiinflam
SE: renal damage fluid rtn aplstic anemia GI ulcers IM ** |
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celecoxib
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reversibly inhib COX2 for only inflamm cells vascular endothelium med inflammation and pain; maintain gastric mucosa
less corrosion tx: RA osteoarthritis pts /w gastritis or ulcers inc risk of thrombosis sufla allergy |
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acetaminophen
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tyleonol, inhib COX reversible CNS inact peripherally
antipyretic analgesic NOT anti-inflamamtrry can use in children w/ viral SE: overdose hepatic necrosis, depletes glutithione toxic tissue adduct in liver N acetylcystein is antidote to regen glutathion, mucolytic prevent contrast induced npehropathy |
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sulfa allergies
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celacoxib, diuretics (furosimide, acetazolamine, thiazide) probenicid, TMP/SMX, sufasalazine, sumatriptan (sorta but not)
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Pencillin G
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syphilis IV
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penicillin V
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oral for gram + prophylaxis of bact endocarditis; meningococcus,
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methicillin
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treats staph penicillinase resistant
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nafcillin
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treats staph penicillinase resistant
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dicloxacillin
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treats staph penicillinase resistant
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ampicillin
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IV rash if given fro mono
may cause C diff wider spectrum penicillinase sensitive use CAST optitis media, gram + and - helps HI, ecoli, listeria proteus salmonella enterococci |
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amoxicillin
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oral
wider spectrum penicillinase sensitive use CAST optitis media, gram + and - helps HI, ecoli, listeria proteus salmonella enterococci |
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ticarcillin
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antipseudomonas gram- rods, carboxy pcn, extenden spectrum use w/ CAST
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carbicillin
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antipseudomonas gram- rods, carboxy pcn, extenden spectrum use w/ CAST
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piperacillin
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antipseudomonas gram- rods, carboxy pcn, extenden spectrum use w/ CAST
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cephalosporins
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do not give w/ aminoglycosides, disulfiram rxn, HS
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cefazolin cephalexin
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gram + PEcK proteus ecoli klebsieta UTI
1st gen |
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cefprozil cefaclor cefuroxime
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2nd gen; HEN PECKS
HI, enterbacter, neisseria serratia; proteus ecoli klebssiela |
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cefotaxime, ceftazidime, ceftriaxone, cefdinir
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3rd gen; HEN PECKs HI, e coli, neisseria, proteus enterobacter, klebsiella
ceftriaxone-neisseria longest HL pesudomonas-ceftazidime |
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cefepime
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4th gen pseudomonas gram + and -
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aztreonam
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monobactam, no HS synergistic w/ aminoglycsides CAN BE USED IN RF NOT NEPHROTOXIC; can give w/ PCN inhib cell wall syn; PBP3
gram - rods only |
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imipenum
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always w/ cilastin prevents kidney extretion; broad spec
b lactamase resistant gram - and + mixed infections seizures DOC for enterobacter HS!!! |
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meropenem
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gram + aerobic mixed infections seizures
DOC for enterobacter HS rxn |
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vancomycin
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binds D-ala D-ala gram + only MRSA endocraditis coag =
C diff oral or metronidazole NOT nephrotoxic, ototoxicty Thrombopheltitis red man sydnroem (antihist) |
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linezolid
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MRSA VRE binds 23S of 50S interacts w/ bact inititation complex; oral
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aminoglycosides
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GNATS do not give w/ nephrotoxic otoxic teratogen inact by acetylation phosphorylation or adenylaton
require O2 so no anaerobes CI w/ cephs, syn w/ B lactam antibiotics an daztreonam |
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gentomycin
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aminoglycoside gram - rods
do not give w/ nephrotoxic otoxic teratogen inact by acetylation phosphorylation or adenylaton require O2 so no anaerobes gram - rods CI w/ cephs, syn w/ B lactam antibiotics an daztreonam |
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neomycin
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bowel sugery gram - rods
aminoglycocide do not give w/ nephrotoxic otoxic teratogen inact by acetylation phosphorylation or adenylaton require O2 so no anaerobes CI w/ cephs, syn w/ B lactam antibiotics an daztreonam |
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amikacin
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aminoglycocide gram - rods
do not give w/ nephrotoxic otoxic teratogen inact by acetylation phosphorylation or adenylaton require O2 so no anaerobes CI w/ cephs, syn w/ B lactam antibiotics an daztreonam |
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tobramycin
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aminoglycocide gram - rods
do not give w/ nephrotoxic otoxic teratogen inact by acetylation phosphorylation or adenylaton require O2 so no anaerobes CI w/ cephs, syn w/ B lactam antibiotics an daztreonam |
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streptomycin
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aminoglycocide gram - rods
do not give w/ nephrotoxic otoxic teratogen inact by acetylation phosphorylation or adenylaton require O2 so no anaerobes CI w/ cephs, syn w/ B lactam antibiotics an daztreonam |
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tetracyclines
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vibrio, acne, chlamdia, uropalsma, mycopalsma, tularemia Hpylori burrelia, rickettsia (VACUM the BEdRoom)
30s static aminoacyltRNA do not tak ew/ milk iron mg antacids divalent cations inhibit absorpiton SE: Gi dstress discolor teeth inhib bone growth, photosensititvyt CI pregnancy |
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doxycycline
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can be used in RF patients
vibrio, acne, chlamdia, uropalsma, mycopalsma, tularemia Hpylori burrelia, rickettsia (VACUM the BEdRoom) 30s static aminoacyltRNA do not tak ew/ milk iron mg antacids divalent cations inhibit absorpiton SE: Gi dstress discolor teeth inhib bone growth, photosensititvyt CI pregnancy |
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demclocycline
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vibrio, acne, chlamdia, uropalsma, mycopalsma, tularemia Hpylori burrelia, rickettsia (VACUM the BEdRoom)
30s static aminoacyltRNA do not tak ew/ milk iron mg antacids divalent cations inhibit absorpiton SE: Gi dstress discolor teeth inhib bone growth, photosensititvyt CI pregnancy |
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minocycline
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bluish discolor ACNE
vibrio, acne, chlamdia, uropalsma, mycopalsma, tularemia Hpylori burrelia, rickettsia (VACUM the BEdRoom) 30s static aminoacyltRNA do not tak ew/ milk iron mg antacids divalent cations inhibit absorpiton SE: Gi dstress discolor teeth inhib bone growth, photosensititvyt CI pregnancy |
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erythromycin
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gut peristalsis
PUS atypical pneumo, URI sTD inhib 23 of 50s INC QT interval, GI rash acut echolestatic cholestatus eosinophilia (inc theophillines and anticoag) |
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clarithromycin
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PUS atypical pneumo, URI sTD
inhib 23 of 50s INC QT interval, GI rash acut echolestatic cholestatus eosinophilia (inc theophillines and anticoag) |
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azithromycin
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PUS atypical pneumo, URI sTD
inhib 23 of 50s INC QT interval, GI rash acut echolestatic cholestatus eosinophilia (inc theophillines and anticoag) |
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chlormaphenicol
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meningitis (cef is better); SE anemia aplastic anemia gray babysyndrome (lack UDP glucoronyl tranferase)
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clindamycin
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anerobic infection 50S narrow spec bacteroids fragilis clostridium, asp pneumo MRSA---C diff
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SMX TMP
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dihydropterate synthase and dihydrofolate reductase; HS reactions G6PD def, nephrotx photsn, kerniccterus; treats marrow poorly (megalobasltic anemia leucopenia)
tx: UTI salmonella shigella PCp pneumo MRSA NOT IN PREG WOMEN |
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nitrofuantoin
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bacteriocidal inact bact ribosomes; UTI cystitis e coli staph saprophyticus SAFE IN PREGNANCY
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floroquinolones
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inhib DNA gyrase topo 2 don't take w/ antacids; dairy caffien bones and groans childrne arthropaty; Gi upset superinfeciton CI preg tendontitis rupture in adults
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ciprofloxacin
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inhib DNA gyrase topo 2 don't take w/ antacids; dairy caffien bones and groans childrne arthropaty; Gi upset superinfeciton CI preg tendontitis rupture in adults
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levofloxacin
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gram - rods, urianry GI neisseria gonorrhea UTI URI
inhib DNA gyrase topo 2 don't take w/ antacids; dairy caffien bones and groans childrne arthropaty; Gi upset superinfeciton CI preg tendontitis rupture in adults |
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moxifloxacin/nor
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gram - rods, urianry GI neisseria gonorrhea UTI URI
inhib DNA gyrase topo 2 don't take w/ antacids; dairy caffien bones and groans childrne arthropaty; Gi upset superinfeciton CI preg tendontitis rupture in adults |
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metronidazole
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FR damage DNA
GET GAP on the Metro giardia, entaemeba trich, gardenella anaerobe H pylori disulfriam rxn |
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polymyxins
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B/E disrupt osmotic PL (mix up membraes)
neurtoxic acut RTN psedumonas topical!! |
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narrow spectrum anaerobic
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clindamycin and metronidazole
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drugs causing ototoxicity and nephrotoxicity
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vancomycin, aminoglycocides, diruetics, cisplatin
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gray man syndrome
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amioderone
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gray baby syndrome
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chloramphenicol
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red man syndrome
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vacomycin
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drugs causing photosensitivity
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tetracyclines, sulfonamides, amiodarone
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drugs causing SJS
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ethosuxamide lamodridine sulfa
OTHERS? |
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sulfa allergy drugs
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thiazide diuretics, acetazolamide furosemide celocoxib probenecid (fever rash hemolyti canmeia TP agrnaulocytosis urticaria hiver photosn)
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disulfiram rxn drugs
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inhib aldehyde DH inc aldehye
metronidazole, cephalosporins, sulfonureas, procarbazine, |
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2 best drugs for MRSA
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vanco and linezolid
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drugs to treat TB
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rifampin, isoniazid, pyrazinamide ethambutol RIPE
poss streptomycin |
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MAC treatment combo
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azithromycin prophylaxis
treat azithromycin rifampin ehtambutol streptomycin |
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treat M leprae w/?
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dapsone rifampin colfazimine
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ethambutol
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treat TB
optic neuropathy (red green color bind) EYE dec carb polymerizaiton of mycobact clel wall block arabinosyl tranferase |
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isoniazid
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INH treats TB dec mycolic acids bact catalase peroxidase need to convert INH to active metab
prophylaxis of TB fast vs slow acetylators neurotox, hepatox, lupus pyridoxine prevents neurtox an dlupus |
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pyrazinamide
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treats TB
acidic pH phagolysosomes Tb engulfed by macs |
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rifampin
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inhibit DNA0dependent
4Rs RNA polymerase, revs up P450, red body fluids, rapid resistance if used alone treats TB, leprosy meingococcal porphylaxis and chemoprophylaxis |
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meningococcal prophylaxis 2
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minocycline and rifampin
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gonorrhea prophylaxis
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ceftriazone
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syphilis prophylaxis
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PCN G
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prophylaxis for UTIs
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SMX/TMP
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jiroveci prophylaxis
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TMP/SMX or pentamiddien
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endocarditit prophylaxis
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surgical dental procedures
PCN |
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MAC prophylaxis
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azithromycin or clarithromycin
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drug induced lupus
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hydralazine, procrainamide, isonizid, phenytoin, sulfa HIPPS
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amphotericin B
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binds ergosterol forms pores treats seroius systemic mycoses
SE: fever chills hypotension nephrotoxic hepatotoxic arrhythemias anemia AMPHOTERRIBLE liposomal form dec toxicity |
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nystatin
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binds ergosterol and forms pores
topical form swish an dswallow for oral thrush topical rash |
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azoles
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inhib ergosterol synthesis inhib P450 inhib lanosteorl to ergost
SE: hormone syntehsis inhib (gynecomastia liver dysfunciton fever chills) hypercortisolism; can suppress testosterone |
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itraconazole
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sporotrich
inhib ergosterol synthesis inhib P450 inhib lanosteorl to ergost SE: hormone syntehsis inhib (gynecomastia liver dysfunciton fever chills) hypercortisolism; can suppress testosterone |
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fluconazole
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cryptococcus
inhib ergosterol synthesis inhib P450 inhib lanosteorl to ergost SE: hormone syntehsis inhib (gynecomastia liver dysfunciton fever chills) hypercortisolism; can suppress testosterone |
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ketoconazole
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systemic, clot/mico for topical
inhib ergosterol synthesis inhib P450 inhib lanosteorl to ergost SE: hormone syntehsis inhib (gynecomastia liver dysfunciton fever chills) hypercortisolism; can suppress testosterone |
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flucocystosine
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inhib DNa synthesis by conversion to 5FU
systemic fungal infections candida crytpococcus w/ amphotericin SE: N/V diarrhea bm suppression |
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caspofungin
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inhib cell wall syn B-glucan
tx invasive aspergillosis SE: gi flushing |
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terbinafine
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inhib squalene epoxidase
inhib ergosteron syn tx dermatophytoses and onychomycoses |
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griseofulvin
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MT fucntion disrupts mitosis deposit
nails oral treatment of superficial infect inhib dermatophytes SE teratogenic carcinogenic confusion HA inc P450 warfain metab |
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pyrimethamine
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plamodial dihydrofolate reductase treats P falciparum and toxo w/ sulfadiazine
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acyclovir valacyclovir
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treats HSV/VZV
TK activates guanosine analog then inhib DNa polymerase prophylaxis in immunocomp |
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famicyclovir
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herpes
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gancilcovir
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5 monophosphate by CMV
act by Tk inhib DNA polym tx CMV SE: luekopenia neutropenia TP reanl tox MORE TOXIC THAN ACYCLOVIR |
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foscarnet
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pyroFOSphate analog
DNA polymerase inhib DOES NOT NEED TK tx CMV nephrotoxic |
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amatadine
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blocks uncoating M2 releases dopamine fro intact nerve temrinals
SE ataxia dizzy slurred speech anticholinergic probs w/ Cb TREATS PARKINSON'S DISEASE NOT INFLUENZA ANYMORE |
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rimandidine
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less SE than amatadine not cross BBB but doesn't treat anything
used to be influenze NOT parkinsons |
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zanamivir oseltamivir
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inhib neuramidinidase
no release of progency treats inlfuenza A/B prophylaxis |
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ribavirin
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syn of guainine nucleotide comp inhib IMP DH
treats Hep C w/ IFN SE: hemolytic anmia SEVERE TERATOGEN |
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-navir
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protease inhib for HIV
inhib cyto P450 pl gene cleaves polypeptide mRNA prevent maturaiton GI intolerance |
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indinavir
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kidney stones insig hyperbilirubiemia and TP glucose and lipid abnormalities
protease inhib for HIV inhib cyto P450 pl gene cleaves polypeptide mRNA prevent maturaiton GI intolerance |
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saquinavir
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glucose/lipid abnl
protease inhib for HIV inhib cyto P450 pl gene cleaves polypeptide mRNA prevent maturaiton GI intolerance inhib necleotide biding rev trancriptase term DNA chain MUST BE POHSHORLYATED BY TK TO BE ACTIVE POSS SE OF LACTIC ACIDOSIS |
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ritonavir
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pancreatitis
protease inhib for HIV inhib cyto P450 pl gene cleaves polypeptide mRNA prevent maturaiton GI intolerance |
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amprenvavir
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glucose changes
protease inhib for HIV inhib cyto P450 pl gene cleaves polypeptide mRNA prevent maturaiton GI intolerance |
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zidovudine
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BM suppresion rev w/ G-CSF and Ep
GI intolerance NRTI for HIV prophylaxis of neonates inhib necleotide biding rev trancriptase term DNA chain MUST BE POHSHORLYATED BY TK TO BE ACTIVE POSS SE OF LACTIC ACIDOSIS |
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dianosine
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NRTI pancreatitis periph neuropathy heaptis teatosis
inhib necleotide biding rev trancriptase term DNA chain MUST BE POHSHORLYATED BY TK TO BE ACTIVE POSS SE OF LACTIC ACIDOSIS |
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zalcitabine
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pancreatitis periph neuropathy
NRTI inhib necleotide biding rev trancriptase term DNA chain MUST BE POHSHORLYATED BY TK TO BE ACTIVE POSS SE OF LACTIC ACIDOSIS |
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satvudine
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pancreatitis periph neuropathy hepatis steatosi
NRTI inhib necleotide biding rev trancriptase term DNA chain MUST BE POHSHORLYATED BY TK TO BE ACTIVE POSS SE OF LACTIC ACIDOSIS |
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lamitidine
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safest NRTI
inhib necleotide biding rev trancriptase term DNA chain MUST BE POHSHORLYATED BY TK TO BE ACTIVE POSS SE OF LACTIC ACIDOSIS |
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NRTI
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inhib necleotide biding rev trancriptase term DNA chain MUST BE POHSHORLYATED BY TK TO BE ACTIVE
POSS SE OF LACTIC ACIDOSIS |
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NNRTIs
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do not need pohsp to be acitve and inhib rev tracritpase
RASH |
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nevirapine
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NNRTI noncomp inhib
do not need pohsp to be acitve and inhib rev tracritpase RASH |
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efavirenz
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false postive cannaboid test
non comp inhib do not need pohsp to be acitve and inhib rev tracritpase RASH |
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declariviridine
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do not need pohsp to be acitve and inhib rev tracritpase
RASH NNRTI non comp inhib |
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enfuviritide
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fusuion inhib
bind viral gp41 inhib conformationchange fusion w/ CD4 SE: HS reactions at subQ inc risk of pneumonia |
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INFa
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tx chornic hep b/c akposis sarcoma
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IFNb
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treats MS
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IFN gamma
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NADPH oxidase def SE neutorpenia
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drugs to avoid in preg
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SAFE Moms Take Really Good Care
sulfonamies (kernicterus), aminoglycosides (NOT), fluorquinolones (cartilage damage), metronidazole (1st tri mutagenesis) tretracylcine (teeth inhib bone growth), ribavirin (antiviral teratogenic), griseofulvin (antifungal teratonenicc) chlormaphenical (grey baby) |
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aldesleukin
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IL-2 RCC malignant melanoma
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filgrastin
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G-CSF for bm IL-3
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sargramostin
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GM-CSF for BM IL-3
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opreleukin
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IL-11 TP
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etanercept
|
RA, psoriasis AK spond
binds Fc IgG and TNF Rc antiTNfa DO NOT GIVE W/ TB |
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adalimumab
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RA psoriasis ank spond
anti TNFa DO NOT GIVE W/ TB |
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infliximab
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crohns RA nk spon mouth Ab
anti TNFa DO NOT GIVE W/ TB |
