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136 Cards in this Set

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Paracetamol Indications

- Mild to moderate pain, usually with other medicines


- Severe pain with other medicines, particularly when transport time is long

Paracetamol Contraindications

- Known severe allergy

Paracetamol Cautions

- Taken in the past 4 hours


- Abdominal pain


- Known severe liver disease

Paracetamol MOA

- Inhibits the production of prostaglandins, resulting in reduced pain and fever

Paracetamol Route

Oral (PO)

Paracetamol Repeat

No

Paracetamol Dose

- 1000mg


- 1500mg for >80kg

Paracetamol Side Effects

None

Ibuprofen Indications

- Mild pain, usually with paracetamol


- Moderate to severe pain with other medicines, usually for long transport time

Ibuprofen Contraindications

- Known severe allergy


- Third trimester pregnancy

Ibuprofen Cautions

- Taken in the past 4 hours


- Age 75 or older


- Known renal impairment


- Clinically significant bleeding


- Known worsening of bronchospasm with NSAIDS


- Pregnancy


- Abdominal pain


- Dehydration or shock


- Known bleeding disorder


- Taking warfarin

Ibuprofen MOA

Ibuprofen is a NSAID used to treat pain. It inhibits activity of the prostaglandin synthetase, reducing prostaglandin production causing reduction in inflammation, pain, and fever

Ibuprofen Route

Oral (PO)

Ibuprofen Repeat

None

Ibuprofen Dose

- 400mg


- 600mg for >80kg

Ibuprofen side effects

- Renal impairment


- Increased bleeding

Aspirin Indications

- Myocardial Ischaemia

Aspirin Contraindications

- Known severe allergy


- Third trimester of pregnancy

Aspirin Cautions

- Known bleeding disorder


- Clinically significant bleeding


- Known worsening of bronchospasm with NSAIDs

Aspirin MOA

- Has antiplatelet, antipyretic, anti-inflammatory, and analgesic effects


- Inhibits cyclooxygenase (COX), causing reduction in production of prostaglandins and thormboxane

Aspirin Route

Oral (PO)

Aspirin Repeat

None

Aspirin Dose

300mg

Aspirin Side Effects

- Increased bleeding

Loratadine Indications

- Minor allergic reaction confined to skin involvement


- Prominent itch associated with anaphylaxis, provided all systemic signs of anaphylaxis have resolved

Loratadine Contraindications

- Known severe allergy


- Age less than 1 year

Loratadine Cautions

- Pregnancy

Loratadine MOA

Non-sedating antihistamine which antagonises (blocks) peripheral histamine receptors, reducing itching and redness

Loratadine Route

Oral (PO)

Loratadine Repeat

None

Loratadine Dose

10mg

Loratadine Side Effects

None

Prednisone Indications

- Bronchospasm associated with asthma/COPD


- Croup


- Prominent rash from anaphylaxis provided all systemic signs of anaphylaxis have resolved


- Minor allergy associated with rash

Prednisone Contraindications

- Known severe allergy

Prednisone Cautions

- Age less than 5 years with asthma

Prednisone MOA

- Metabolised to prednisolone in the liver


- A corticosteroid with anti-inflammatory and immunosuppressant mediators. Inhibits production of inflammatory mediators

Prednisone Route

Oral (PO)

Prednisone Repeat

None

Prednisone Dose

40mg

Prednisone Side Effects

- Fatigue


- Sodium/water retention


- Gastrointestinal reflux

GTN Patch Indications

- CPO not rapidly responding to GTN spray


- Control of hypertension associated with autonomic dysreflexia not rapidly responding to GTN spray


- Control of hypertension prior to fibrynolysis for STEMI


- Control of hypertension during inter hospital transfer for STEMI


- Control of hypertension during IHT for stroke clot retrieval

GTN Patch Contraindications

- Known severe allergy


- Heart rate <40/min


- Heart rate >150/min


- Systolic BP <100mmHg


- Ventricular tachycardia

GTN Patch Cautions

- STEMI, particularly with right ventricle involvement


- Pt is small, frail, or physiologically unstable


- Poor perfusion


- Dysrhythmias


- Medicine for erectile dysfunction in past 24 hours


- Known aortic/mitral stenosis

GTN Patch MOA

Vasodilator which acts on vascular smooth muscle to cause venous and arterial vasodilation, predominantly on veins

GTN Patch Route

Transdermal

GTN Patch Repeat

None

GTN Patch Dose

Patch releases approx 0.5mg per hour

GTN Patch Side Effects

- Headache


- Hypotension


- Flushing


- Tachycardia


- Light-headedness

GTN Spray Indications

- Myocardial ischaemia


- CPO


- Control of hypertension associated with autonomic dysreflexia


- Control of hypertension prior to fibrynolitic treatment for STEMI


- Control of hypertension during inter-hospital transfer for STEMI

GTN Spray Contraindications

- Known severe allergy


- Heart rate <40/min


- Heart rate >150/min


- Systolic BP <100mmHg


- Ventricular tachycardia

GTN Spray Cautions

- STEMI, particularly with right ventricle involvement


- Pt is small, frail, or physiologically unstable


- Dysrhythmias


- Medicine for erectile dysfunction in past 24 hours


- Known aortic or mitral stenosis

GTN Spray MOA

Vasodilator which acts on vascular smooth muscle to cause venous and arterial vasodilation, with predominant effect being on veins

GTN Spray Route

Sublingual

GTN Spray Repeat

Every 3-5 mins for myocardial ischaemia or CPO, increasing to 10 mins of caution is present


- Every 3-5 mins for control of hypertension

GTN Spray Dose

- 0.4mg


- 0.8mg for CPO

GTN Spray Side Effects

- Headache


- Hypotension


- Flushing


- Tachycardia


- Light-headedness

Nebulised Adrenaline Indications

- Moderate to severe stridor

Nebulised Adrenaline Contraindications

None

Nebulised Adrenaline Contraindications

None

Nebulised Adrenaline MOA

- Stimulates adrenoreceptors A1, B1, B2


- A1 for smooth muscle contraction and vasoconstriction


- B1 for increased cardiac contractility, electrical conduction and heart rate


- B2 for smooth muscle relaxation, skeletal muscle vasodilation, bronchodilation, and stabilisation of mast cells


- Primary target for nebulised adrenaline is bronchodilation and smooth muscle relaxation

Nebulised Adrenaline Route

Nebulised

Nebulised Adrenaline Repeat

Every 10 mins as required

Nebulised Adrenaline Dose

5mg/5ml

Nebulised Adrenaline Side Effects

- Tachycardia


- Myocardial ischaemia


- Hypertension


- Tremor/anxiety/sweating


- Tachydysrhythmias


- Ventricular ectopy


- Nausea/vomiting


- Hyperglycaemia

IM Adrenaline Indications

- Anaphylaxis


- Severe asthma

IM Adrenaline Contraindications

None

IM Adrenaline Cautions

- Myocardial ischaemia


- Tachydysrhythmias

IM Adrenaline MOA

- Stimulates A1, B1, B2 receptors


- A1 for smooth muscle contraction, vasoconstriction


- B1for increased cardiac contractility, heart rate


- B2 for smooth muscle relaxation, skeletal muscle vasodilation, bronchodilation, stabilisation of mast cells

IM Adrenaline Route

Intramuscular

IM Adrenaline Repeat

- Every 10 mins if deteriorating for asthma


- Every 5 mins if deteriorating for anaphylaxis, every 10 mins if not improving

IM Adrenaline Dose

0.5mg/0.5ml

IM Adrenaline Side Effects

- Tachycardia


- Tachydysrhythmia


- Myocardial ischaemia


- Ventricular ectopy


- Hypertension


- Nausea/vomiting


- Tremor/anxiety/sweating


- Hypergylcaemia

IN Adrenaline Indications

- Mild epistaxis if bleeding is not controlled with firm pressure for 15 mins


- Moderate to severe epistaxis

IN Adrenaline Contraindications

None

IN Adrenaline Cautions

- Myocardial ischaemia


- Tachydysrhythmias

IN Adrenaline MOA

- Stimulates adrenoreceptors A1, B1, B2


- A1 for smooth muscle contractions, vasoconstriction


- B1 for increased cardiac contractility, heart rate


- B2 for smooth muscle relaxations, skeletal muscle vasodilation, bronchodilation, stabilisation of mask cells


- Primary target being A1 for vasoconstriction

IN Adrenaline Route

Intranasal

IN Adrenaline Repeat

After 20 mins if bleeding doesn’t stop or recurs

IN Adrenaline Dose

- 0.2mg to 1:10,000 solution per nostril




- 1mg ampoule drawn up with 9ml saline, 2ml of solution per nostril

IN Adrenaline Side Effects

- Tachycardia


- Tachydysrhythmia


- Myocardial ischaemia


- Ventricular ectopy


- Hypertension


- Nausea/vomiting


- Tremor/anxiety/sweating


- Hyperglycaemia

Topical Adrenaline Indications

- Clinically significant bleeding from wounds

Topical Adrenaline Contraindications

None

Za

Topical Adrenaline Cautions

- Myocardial ischaemia


- Tachydysrhythmia

Topical Adrenaline MOA

- Stimulates adrenoreceptors A1, B1, B2


- A1 for smooth muscle contractions, vasoconstriction


- B1 for increased cardiac contractility, heart rate


- B2 for smooth muscle relaxations, skeletal muscle vasodilation, bronchodilation, stabilisation of mask cells


- Primary target being A1 for vasoconstriction

Topical Adrenaline Route

Topical

Topical Adrenaline Repeat

As required (PRN)

Topical Adrenaline Dose

- 2mg-5mg, always 1:10,000


- For example, 2mg adrenaline diluted in 18ml saline (1:10,000)

IN Adrenaline Side Effects

- Tachycardia


- Tachydysrhythmia


- Myocardial ischaemia


- Hypertension


- Ventricular ectopy


- Nausea/vomiting


- Tremor/anxiety/sweating


- Hyperglycaemia

Nebulised Salbutamol Indications

- Bronchospasm secondary to asthma/COPD


- Prominent bronchospasm secondary to airway burns, smoke inhalation, chest infection


- Release syndrome following crush injury

Nebulised Salbutamol contraindications

- Known severe allergy

Nebulised Salbutamol Cautions

None

Nebulised Salbutamol MOA

Bronchodilatior, stimulates B2 receptors (smooth muscle relaxation, skeletal muscle vasodilation, bronchodilation, stabilisation of mast cells)

Nebulised Salbutamol Route

Nebulised

Nebulised Salbutamol Repeat

As required (no max dose)

Nebulised Salbutamol Dose

5mg/2.5ml

Nebulised Salbutamol Side Effects

- Tremor


- Tachycardia

Nebulised Ipratropium Indications

- Bronchospasm secondary to asthma/COPD


- Bronchospasm secondary to airway burns, smoke inhalation, chest infection

Nebulised ipratropium Contraindications

- Known severe allergy

Nebulised ipratropium Cautions

None

Nebulised ipratropium MOA

- Bronchodilator


- Anticholinergenic agent with antimuscarinic activity. Antagonises (blocks) acetylcholine receptors causing vagal inhibition resulting in bronchodilation

Nebulised Ipratropium Route

Nebulised

Nebulised Ipratropium Repeat

None

Nebulised Ipratropium Dose

0.5mg/2ml

Nebulised Ipratropium Side Effects

- Tremor


- Dry mouth


- Blurred vision

IM Ondansetron Indications

- Clinically significant nausea/vomiting

IM Ondansetron Contraindications

- Known severe allergy


- Age <1 year

IM Ondansetron Cautions

None

IM Ondansetron MOA

Antagonises (blocks) serotonin receptors centrally in the brain and peripherally in the GI tract, causing reduction in nausea/vomiting

IM Ondansetron Route

Intramuscular

IM Ondansetron Repeat

Once after 20 mins

IM Ondansetron Dose

4mg/2ml

IM Ondansetron Side Effects

- Headache


- Flushing

Methoxyflurane Indications

- Moderate to severe pain when IV analgesia is not available


- Moderate to severe pain when IV analgesia is not appropriate to administer

Methoxyflurane Contraindications

- Known severe allergy


- Personal or family history of malignant hyperthermia


- Known renal impairment


- Unable to obey commands


- Had Methoxyflurane in the past week

Methoxyflurane Cautions

- 75 years or older


- Pre-eclampsia


- Administration within a confined space

Methoxyflurane MOA

MOA is unclear, however Methoxyflurane is an inhaled analgesic used to relieve pain

Methoxyflurane Route

Inhaled

Methoxyflurane Repeat

Once if pt is 12 years or older

Methoxyflurane Dose

3ml undiluted

Methoxyflurane Side Effects

- Sedation


- Light-headedness

Glucose Gel Inidications

- Hypoglycaemia in adults/children provided they are able to swallow


- Hypoglycaemia in neonates

Glucose Gel Contraindications

None

Glucose Gel Cautions

None

Glucose Gel MOA

Source of glucose which is easily swallowed and quickly absorbed

Glucose Gel Route

Oral (PO)

Glucose Gel Repeat

Every 10 mins as required

Glucose Gel Dose

10-20g (1 sachet, 18g)

Glucose Gel Side Effects

None

Glucagon Indications

Hypoglycaemia where the patient cannot swallow and IV access is unavailable

Glucagon Contraindications

Known severe allergy

Glucagon Cautions

None

Glucagon MOA

Stimulates glycogenolysis within the liver, breaking down glycogen into glucagon which is released into the bloodstream

Glucagon Route

Intramuscular

Glucagon Repeat

None

Glucagon Dose

- 1mg/1ml


- 0.5mg for under 5 years old

Glucagon side effects

None