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34 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Atropine-like side effects (4)
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TCAs
Typical neuroleptics (low potency) 1st generation anti-histamines Amantidine |
TATA? I'm grasping at straws here...
TATAs make me RED & HOT... (2 signs of atropine overdose) |
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Torsades de pointes (6)
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Pretty much anything that prolongs the QT interval:
Antiarrhythmics: class III, class IA Macrolides Neuroleptics (antipsychotics): Haloperidol/risperidone Malaria drugs: Chloroquine/mefloquine Methadone Protease inhibitors |
Wow I wish I had a mnemonic for this.... maybe 3M & PAN?
Like, "MMM, a NAP sounds good..." See p 262 |
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Agranulocytosis (6)
KNOW THIS ONE |
Clozapine
Carbamazepine Colchicine Propylthiouracil Methimazole Dapsone |
Three drugs all start with C and end with -ine.
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Aplastic anemia (5)
KNOW THIS ONE |
Chloramphenicol
Methimazole NSAIDs Benzene Propylthiouracil (PTU) |
Can't Make Normal Bone Products
Note: PTU & methimazole have the same mechanism - if you can remember one, hopefully you can remember the other! |
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Direct Coombs-positive hemolytic anemia
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Methyldopa
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Direct Coombs - to find Abs attached to RBCs in vivo
Indirect Coombs - to find anti-human Abs in serum |
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Gray baby syndrome
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Chloramphenicol
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Hemolysis in a G6PD-deficiency patient
(There's a lot... I list 9.) |
Drugs that cause oxidative stress
Isoniazid (INH) Sulfonamides Primaquine Aspirin (esp. in high doses) Ibuprofen Nitrofurantoin (used for UTIs, cystitis) Dapsone Naphthalene Fava beans |
"Hemolysis IS PAIN":
Isoniazid, Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin |
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Megaloblastic anemia
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PMS:
Phenytoin Methotrexate (MTX) Sulfa drugs 5-fluorouracil (5FU) Hydroxyurea |
having a "blast" with PMS
Alternative: MAPLE Methotrexate AZT (Zidovudine) Phenytoin Liver disease Ethanol And, of course, folic acid or B12 deficiency |
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H2 Blockers (cimetidine etc.)
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CYP 450 inhibition
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Amiodarone
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pulmonary fibrosis
thyroid dysfunction hepatotoxicity check PFTs, LFTs, & TFTs |
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Acute cholestatic hepatitis
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Macrolides
Erythromycin is contraindicated in liver disease |
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Focal to massive hepatic necrosis (3)
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Halothane
Acetaminophen (>4g daily is toxic) Amanita phalloides Valproate |
you HAAV a massive hepatic necrose
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Hepatitis
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INH
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Pseudomembranous colitis
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Clindamycin
Ampicillin |
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Adrenocortical insufficiency
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Glucocorticoid withdrawal
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(chronic suppression of the hypothalamus-pituitary-adrenal axis)
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Gynecomastia (7)
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Spironolactone
Digitalis Cimetidine Alcohol (chronic use) Marijuana Ketoconazole Estrogens Non-drug causes: Klinefelter's syndrome, cirrhosis, testicular tumor, puberty, old age) |
Spome Dirugs Cireate Alsome Male Kenockers
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Hot flashes
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SERMS: Tamoxifen, clomiphene
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Gout (2)
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Furosemide
Thiazides Contraindicated in hyperuricemia |
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Osteoporosis (2)
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Corticosteroids (chronic use)
Heparin |
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Photosensitivity (3)
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Sulfonamides
Amiodarone Tetracyclines |
SAT for a photo
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Stevens-Johnson syndrome (8)
awful-looking rash... google it. |
Ethosuximide
Lamotrigine Carbamazepine Phenobarbital Phenytoin Sulfadrugs Penicillin Allopurinol |
"Seizures, Sulfas, & 'Cillins"
Seizure meds Sulfa drugs peniCillin derivatives ..... plus allopurinol. |
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Drug-induced lupus (7)
(SLE-like syndrome) |
Sulfasalazine
Hydralazine Isoniazid Procainamide Phenytoin Sulfonamides Statins |
Or, it's not HIPP to have lupuSSS
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Fanconi's syndrome (3)
proximal tubule failure causes nutrient wasting in urine |
Expired tetracycline
Heavy metal exposure Wilson's disease (excess Cu) |
WE Hate Fanconi's syndrome
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Interstitial nephritis (3)
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Methicillin
NSAIDs Furosemide |
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Hemorrhagic cystitis
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Cyclophosphamide
Can be prevented with mesna |
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Cinchonism (2)
headache, dizziness, vision change, tinnitus |
Quinidine
Quinine |
The "Quin"s (rhymes with "Cin")
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Nephrogenic diabetes insipidus (2)
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Lithium (treat with HCTZ & Ameloride)
Demeclocycline |
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Parkinson-like syndrome (5)
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High-potency neuroleptics: haloperidol, chlorpromazine, reserpine
Metoclopramide |
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Seizures
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Bupropion
Benzodiazepine or alcohol withdrawal Imipenem/cilastatin Isoniazid (INH) Enflurone Evening primrose oil |
BB
II EE Not exactly a mnemonic, but it could help... Think of someone stuttering these syllables while having a seizure |
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Disulfram-like reaction (4)
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Metronidazole
Some cephalosporins 1st generation sulfonylureas (chlorpropamide, tolbutamide) |
diCEPHuruM
These keep coming up; they're probably important. |
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Nephrotoxicity & ototoxicity (4)
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Aminoglycosides
Vancomycin Loop diuretics Cisplatin |
Aminoglycosides - NOT: Nephrotox, Ototox, Teratogenic
Vancomycin - NOT: Nephrotox, Ototox, Thrombophlebitis |
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P450 inhibition
(causing dec. metabolism) |
Protease inhibitors
Isoniazid Cimetidine Ketoconazole Erythromycin, Ethanol (ACUTE use) Grapefruit juice Sulfonamides |
INHIBIT yourself from drinking from a KEG or you'll be ACUTEly SICk
(this one leaves out the HIV protease inhibitors) PICK EGS (think of Easter) |
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P450 induction (8)
(causing inc. metabolism) |
Quinidine
Barbiturates St. John's wort Phenytoin Rifampin Griseofulvin Carbamazepine Alcohol (chronic use) |
QUINe BARB Steals PHEN-phen and RIFuses GRISE CARBs and ALCOHOL.
I'm sure there's a better mnemonic, but I haven't had the time to find or make one... |
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common Aminoglycosides
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Gentamycin
Tobramycin Amikacin |
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