Drug Therapy For Htn

Front 1

Inhibit NaCl reabsorption in distal convoluted tubule, increase Sodium and cl excretion, initial decrease in ECF, sustained decrease in SVR

Back 1

Thiazide, hydrochlorothiazide, metolazone, indapamide

Front 2

Monitor for orthostatic hypotension, hypokalemia, alkalosis, may potentiate cardiptoxicity of digoxin by producing hypokalemia

Back 2

Thiazides, indapamide, metolazone

Front 3

NSAIDs may decrease diuretic and antihypertensive effect of

Back 3

Thiazide diuretics

Front 4

Inhibit NaCl reabsorptin in ascending loop of henle, increase secretion of na and cl, more potent than thiazide, shorter duration, less effective for HTN

Back 4

Loop diuretics

Front 5

Monitor orthostatic hypotension and electrolyte imbalances, this drug remains effective despite renal deficiency, effect increases with higher dose

Back 5

Loop diuretics

Front 6

Reduce k and na exchange at distal + collecting tubules, reduce excretion of k, h, ca, and mg

Back 6

Potassium-sparing diuretic

Front 7

Potassium-sparing diuretic and aldosterone receptor blocker

Back 7

Monitor for orthostatic hypotension and hyperkalemia

Front 8

Potassium-sparing diuretic is contraindicated in those with

Back 8

Renal failure

Front 9

If pt takes potassium-sparing diuretic use with caution when pts also using ------ and ------.

Back 9

ACE inhibitor and angiotension II blocker

Front 10

Pt should avoid ------- when taking potassium-sparing diuretic

Back 10

Potassium supplements

Front 11

Clonidine

Back 11

Reduces sympathetic outflow from CNS

Front 12

Sudden d/c of ------- can cause withdrawal syndrome including rebounspd hypertension, tachycardia, headache, tremors, apprehension and sweating

Back 12

Adrenergic inhibitor- central acting or a-adrenergic antagonist

Front 13

Peripheral-acting aadrenergic antagonist

Back 13

Prevents peripheral release of norepinephrine which results in vasodilation, lowers CO and reduces sbp more than dbp

Front 14

May cause severe orthostatic hypotension, not recommended for older adults or pts with cerebrovascular/coronary insufficiency

Back 14

Peripheral-acting adrenergic antagonist

Front 15

Guanathidine (peripheral-acting aadrenergic antagonist

Back 15

Rise slowly, wear support stockings, hypotensive effect may be delayed by 2-3 days and lasts 7-10 after withdrawal

Front 16

Guanadrel, reserpine (peripheral-acting aadrenergic antagonist

Back 16

Must be two times daily, not for pt with hx of depression, monitor mood and ment l status, avoid barbiturates, alcohol and opioids

Front 17

A1-adrenergic blocker

Back 17

Reduced resistance to outflow of urine in benign prostatic hyperplasia, take at bedtime to reduce risk of orthostatic hypotension

Front 18

Cardio selective beta blocker

Back 18

Monitor bp and pulse regularly, caution with pts who have dm because it can depress tachycardia that is associated with hypoglycemia, lose cardioselective activity at high doses

Front 19

Esmolol

Back 19

Iv only

Front 20

Nonselective beta blocker

Back 20

May cause bronchospasm, especially for those with asthma

Front 21

Alpha+beta blockers are

Back 21

Carvedilol and labetalol

Front 22

Mixed a and b blockers

Back 22

Iv form for hypertensive crisis, must be kept supine during iv admin

Front 23

When using carvedilol or labetalol, assess pt for

Back 23

Tolerance of upright position before allowing upright activities

Front 24

Direct vasodilator fenoldopam

Back 24

Iv use only for hypertensive crisis in hospital, use cautiously with pt who have glaucoma, remain in supine position for 1 hour