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56 Cards in this Set

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Drug w/ atropine like side effects
TCAs
Drug(s) that present with coronary vasospasms
cocaine, sumatriptan

Suma-wrestlers take cocaine and their vessels spasm with anger
Drug(s) that present with cutaneous flushing
VANC
Vancomycin
Adenosine
Niacin
Calcium channel blockers

"Aden had a NICE light blue VAN that had a great heater. (it would be flushingly warm)"
Drug(s) that present with interstitial nephritis
Methicillin, NSAIDs, Furosemid

"The kidney was FURious bc you took meth and NSAID which gave it interstitial nephritis"
Drug(s) that present with Hemorrhagic cystitis
Cyclophosphamide, ifosfamide (prevent by coadministrating with mesna)
Drug(s) that present with Cinchonism
Quinidine, quinine
Drug(s) that present with Diabetes insipidus
Lithium, demeclocycline

Demeclocycline causes Diabetes
Drug(s) that present with parkinson-like syndrome
Haloperidol, Chlorpromazine, reserpine, metoclopramide
Drug(s) that present with Seizures
Bupropion, imipenem/cilastin, isoniazid

"the pen is bupping"
Drug(s) that present with Tardive dyskinesia
Antipsychotics
Drug(s) that present with Disulfram-like reactions
Metronidazole, procarbazine, 1st generation sulfonylureas, cefoperazone, and cefamandole.

"The family metro-sexual, fobby, was pro-carbs and sulky. "
Drug(s) that present with nephrotoxicity/ neurotoxicity
Polymyxins
Drug(s) that present with nephrotoxicity/ototoxicity
Aminoglycosides, vancomycin, Loop diuretics, cisplatin

"A mean guy jumped out of a van, looped up and cisplanted a punch in the ear and kidney"
p-450 inducers
Quinine, Barbituarates, St John's wort, Phenytoin, Rifampin, Griseofulvin, Carbamazepine

Queen Barb Steals Phen-phen and Refuses Greasy Carbs Chronically
p-450 inhibitors
Sulfonamides, Isoniazid, Cimetidine, Ketoconazole, Erythromycin, Grapefruit juice. Acute alcoholic use

Inhibit yourself from drinking beer from a KEG because it makes you Acutely SICk
Tx for status elipticus seizures?
Phenytoin and Benzodiazepines

Penny wanted her gin and tonic STAT
Phenytoin
"Penny needed her SALTY gin and TONIC STAT. She was an ugly girl with gingival hyperplasia, a mustache, megaloblastic anemia (skinny) and a cleft lip. She also had a malar birth defect and was cross-eyed. She was also retarded and had a small head since birth.

Na channel inactivation, Tonic-clonic seizures, Status elepticus, gingival hyperplasia in children, hirsutism, megaloblastic anemia, cleft lip defect in neonates, also fetal hydantoin syndrome diplopia.
Carbamazepine toxicity
-1st line for Tonic-Clonic seizures and tigeminal neuralgia

Open your jaw and drink tonic water but know it has lots of Carbs.

Car goes BAM: blood everywhere (blood dyscrasias), hit in eye, head and liver (induction of cytochrome P-450, diplopia, ataxia), scrape your skin (steven's johnson), Cut your lip and spine (cleft lip, spina bifida), lay there for awhile and get really thirsty (SIADH)
Ethosuximide toxicity
ETHyl never wanted to SUX her husband, STEVEN's JOHNSON, so she would say she had a stomach ache (GI distress), was TIRED had a HEADACHE, or was too ITHCY
Ethosuximide clinical use
Absent siezures and blocks thalamic T-type Calcium channels

"ETHyl was ABSENT minded and big BONED"
Valproic acid clinical use
used for Partial and all generalized except for status. Increased NA channel inactivation and increases GABA concentration

"VAL he Vally girl was ABSENT minded and liked to drink SALTY gin and TONICs while GABbing constantly"
Valproic acid toxicity
GI distress, hepatotoxicity (measure LFTs), neural tube defects, tremor, weight gain, C/I in preggers

"VAL drank all the time so had a BAD LIVER and PUKED. This made her FAT Unfortunately she was PREGGERS so her baby had SPINA-BIFIDA"
Lamotrigine toxicty
Steven's johnson

"Steven's johnson was lame"
Niacin mechanism
inhibits lipolysis in adipose tissue; reduces hepatic VLDL secretion into circulation
-Statin mechanism
inhibit cholesterol pre-cursor, mevalonate. HMG-CoA reductase inhibitors
Bile acid resins (cholestyramine, colestipol, colesevelam) mechanism
Prevent intestinal reabsorption of bile acids; liver must use cholesterol to make more
Cholsterol absorption blockers (ezetimibe) mechanism
Prevent cholesterol reabsorption at small intestine brush border

"its EZ to block cholesterol in the small intestine!"
-Fribrates mechanism
Upregulate lipoprotein lipase and increasing TG clearance. Promotes breakdown of VLDL

"Fibrates (+) lipase"
Theophylline
-long term for asthma
-inhibits phosphodiesterases and decreases cAMP hydrolysis
-usage is limited bc of the narrow therapeutix index
-causes dry mouth
-blocks actions of adenosine
Ketamine
-Arycyclohexylamines used for IV anesthesia
-PCP analogs that act as dissociative anesthetics. Blocks NMDA receptors. Cardio stimulants. Cause diorentation, hallucinations and bad dreams. Increase cerebral blood flow.

Think of Alice in wonderland's key
Bleomycin clincial use
Testicular cancer, Hodgkin's lymphoma (Part of the ABVD regimen for Hodgkin's)

B for Balls
Bleomycin toxicity
Pulmonary fibrosis, skin changes but minimal myelosuppression

When you rub Balls guys get flushed (skin changes) and breath heavy (pulmonary fibrosis)
Mechanism of Bleomycin?
Gs-phase specific. Induces formation of free radicals which cause breaks in DNA

"Bleomycin Breaks DNA"
Dactinomycin (actinomycin D)
-Intercalactes in DNA
-Wilm's tumor, Ewing sarcoma, rhabdomyosarcoma. Used for childhood tumors. Toxic myelosuppression

"children ACT out"
Doxorubicin (Adriamycin, daunorubicin) mechanism
generate free radicals. Noncovalently intercalate in DNA --> breaks in DNA --> decrease replication

The Doxin ran free
Doxorubicin (Adriamycin, daunorubicin) clinical use
part of the ABVD combination in Hodgkins. Myelomas, sarcomas, solid tumors (breast, ovary lung)

oh MY, the woman with the DOXin HOD big breasts
Doxorubicin (Adriamycin, daunorubicin) toxicity
cardiotoxicity. Toxic to tissues with extravasion

The Doxin, who had cancer, had a big heart
Best drug to use for generalized anxiety?
Busipirone (doesn't cause sedation, addiction or tolerance. Doesn't interact with alcohol

This drug is great! Gotta get on that BUS
MAO inhibitors (list)
Phenelzine, tranylcypromine, isocarboxazid, selegiline

"Phez the Trany is Selective"
Clinical use of MAO inhibitors?
Atypical depression, anxiety, hypochondriasis
Toxicity of MAO inhibitors?
Hypertensive crisis with tyramine ingestion (in many foods, such as wine and cheese) and B-agonists. CNS stimulation. C/I with SSRIs or meperidine
SNRIs
-Venlafaxine, duloxetine
-inhibit serotonin and NE reuptake

Duel for Vengence to stop the serotonin and NE!
Trazodone
-inhibits serotonin reuptake. Used for insomnia
-causes sedation, nausea, priapism and postural hypotension


trazBONE
Bupropion
-smoking cessation
-increase NE and dopamine
-causes stimulant effects, headache and seizure in bulimic pts
-no sexual side effects

Don't use Bupropion in Bullemics
Drug used to treat onychomycosis?
-Mechanism of this drug?
Terbinafine.
inhibits the fungal enzyme squalene epoxidase

"wrap the TURBINE around your nails and SQUash the fungus out of them"
Drug thats an oral treatment of superficial infections such as tinea and wring worm?
Griseofulvan

"greasy fulcrum"
Mechanism of Griseofulvan?
Interfers with microtubule function: dirupts mitosis. Deposits in keratin-containing tissues (nails)

Greasy fulcrum gets rid of dermatophyte infections on your "toesis" (mitosis)
Nyastatin mechanism and use?
Binds to ergosterol disrupting fungal membranes. Too toxic for systemic use

"swish and swallow" for oral candidiasis (thrush); topical for diaper rash or vaginal candidiasis
Mechanism of Amphotericin B?
Binds to ergostol; forms membrane pores that allow leakage of eletrolytes

Think of a frog blowing up the fungal membrane and also the kidney (nephrotoxicity)
Toxicity of Amphotericin B?
Fever/chills ("shake and Bake"), hypotension, nephrotoxicity, arrythmias, anemia, IV phlebitis.

'When some people see amphibians their faces go white (anemia), they get the chills, and their heart jumps"
Methotrexate mechanism
-Folic acid analog that inhibits dihyfrofolate reductase--> decreases dTMP ---> decreases DNA and decreases protein synthesis

"REX the METH head did not eat enough protein bc all he ate were folic acid vitamins he found"
Clinical use of MTX?
Cancers: Leukemias, Lymphomas, Choriocarcinoma, sarcomas.
non-neoplastic: abortion, ectopic pregnancy, rheumatoid arthritis, psoriasis
Toxicity of MTX
REX the METH head had a really bad liver because even though he didn't eat protein he was really fat (macrovescular fatty change in liver). He's icky and has mouth ulcers and you don't want him near your baby! (mucositis; teratogenic)
Tricyclic antidepressant side effects
sedation: alpha effects, atropine-like side effects (ant-muscarinic). Can cause rapid shift to mania

Desipramine is the least sedating and has lower seizure threshold.

i.e. Tremor, insomnia, conduction defects, arrythmias, hypotension, hyperthermia, flushing, dilated pupils. histamine (sedation)
Lithium side effects?
LMNOP
Movement
Nephrogenic diabetes insipidus
HypOthyroidism
Pregnancy problems
Antibiotics to avoid in pregnancy
Sulfonamides - Kernicterus
Aminoglycosides - ototoxicity
Flouroquinolones - cartilage damge
Erythromycin - acute cholestatic hepatitis in mom
Metronidazole - mutogenesis
Tetracyclines - discolored teeth, inhibition of bone growth
Ribavirin - teratogenic
Griseofulvin - teratogenic
Chloramphenicol - gray baby

SAFE Moms Take Really Good Care

-"Sulfur turns babies yellow"
-"A mean guy hits babies' ears
-"the flock of sinners dance on tops of babies and damage their cartilage"
-A wreath is put on mommy's grave when she dies of hepatitis"
-"only mutants take the metro"
-"the tet offensive has messed up teeth and bones"
-"greesy ribs are just not good for babies"