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41 Cards in this Set
- Front
- Back
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Tricyclics cause
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atropine-like side effects
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Cocaine and sumatriptan cause
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coronary vasospasms
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Niacin, Calcium channel blockers, adenosine and vancomycin cause
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cutaneous flushing
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Doxorubicin (adriamycin) and daunorubicin cause
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dilated cardiomyopathy
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Class III (sotalol) and class IA (quinidine) antiarrhythmics and cisapride cause
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torsades des pointes
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Clozapine, carbamazepine, colchicine, propylthiouracil and methimazole cause
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Agranulocytosis
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Chloramphenicol, benzene, NSAIDs, propylthiouracil and methimazole can cause
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aplastic anemia
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Methyldopa can cause
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a direct Coombs-positive hemolytic anemia
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Chloramphenicol can cause
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Gray baby syndrome
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Isoniazid, sulfonamides, primaquine, aspirin, ibuprofen, nitrofurantoin cause
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hemolysis in G6PD deficient patients
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Oral contraceptives cause
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thrombotic complications
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ACE inhibitors (NOT ARBs like losartan) cause
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COUGH!
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Bleomycin (induces DNA breaks), busulfan and amiodarone cause...
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pulmonary fibrosis
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Macrolides cause
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acute cholestatic hepatitis
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Halothane, valproic acid, acetaminophen and Amanita phalloides cause
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focal to massive hepatic necrosis
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INH can cause
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hepatitis!!
as well as hemolysis in G6PD-deficient patients |
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Clindamycin and ampicillin can cause
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pseudomembranous colitis
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Glucocorticoid withdrawal (HPA suppression) can cause
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adrenocortical insufficiency
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***Spironolactone, digitalis, cimetidine, chronic alcohol use, estrogens and ketoconazole
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GYNECOMASTIA!!!
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tamoxifen (estrogen receptor blocker), clomiphene (SERM) can cause
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hot flashes
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Phenytoin can cause
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gingival hyperplasia
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Furosemide and thiazides can cause
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gout
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Corticosteroids and heparin can cause
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osteoporosis
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Sulfonamides, amiodarone, tetracyclines can cause...
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photosensitivity (SAT for a photo)
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Hydralazine, INH, procainamide, phenytoin can cause...
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SLE-like symptoms
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Fluoroquinolones!
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tendonitis, tendon rupture and cartilage damage (kids)
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Expired tetracycline can cause
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Fanconi's syndrome
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Methicillin and NSAIDs can cause
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interstitial nephritis
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***Cyclophosphamide, ifosfamide (nitrogen mustard alkylating agent) can cause...
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hemorrhagic cystitis (can be prevented using mesna)
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Quinidine and quinine can cause...
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cinchonism (hearing loss, dizziness and ringing in the ears)
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Lithium and demeclocycline can cause
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diabetes insipidus
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Buproprion and imipenem/cilistatin can cause...
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seizures
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Antipsychotics can cause...
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tardive dyskinesia
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Metronidazole, certain cephalosporins, procarbazine and 1st-generation sulfonylureas can cause...
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a disulfiram-like reaction!!
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Polymyxins can cause...
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nephrotoxicity and neurotoxicity
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Aminoglycosides, loop diuretics and cisplatin can cause...
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nephrotoxicity and ototoxicity!!!
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Quinidine, barbiturates, phenytoin, rifampin, griseofulvin, carbamazepine and St. John's wort are...
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p-450 inducers!!!
(quinidine can do both, but induction is the more important event) |
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Isoniazid, sulfonamides, cimetidine, ketoconazole, erythromycin and grapefruit juice are...
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p-450 inhibitors!!!
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Ethylene glycol toxicity
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this is anti-freeze
can produce oxalic acid which leads to acidosis and nephrotoxicity |
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Methanol toxicity
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can lead to formaldehyde and formic acid
can cause severe acidosis, retinal damage |
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Ethanol toxicity
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increases acetaldehyde which causes nausea, vomiting, headache, hypotension...
(can inhibit alcohol dehydrogenase with fomepizole and acetaldehyde dehydrogenase with disulfiram...acetaldehyde dehydrogenase causes acetic acid build-up) |
