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30 Cards in this Set
- Front
- Back
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fluoxetine, sertraline, or quinidine + codeine
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Decreases effectiveness of codeine
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digoxin + quinidine, amiodarone, or verapamil
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Increases digoxin level by 25-100% and bradycardia
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grapefruit juice + lovastatin, atorvastatin, or nifedipine
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Increases lovastatin, atorvastatin, or nifedipine levels
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cyclosporine + rifampin or St. Johns Wort
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Decreases cyclosporine levels
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cyclosporine + erythromycin or ketoconazole
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Increases cyclosporine levels
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warfarin + miconazole vaginal cream
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Increased anticoagulation
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propanolol + diltiazem or verapamil
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Additive bradycardia
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theophylline + erythromycin or ciprofloxacin
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Increases theophylline concentration; decreases erythromycin concentration
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albuterol + propanolol
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Decreases bronchodilation
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sildenafil + nitroglycerin or isosorbide dinitrate
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Additive hypotension
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ciprofloxacin + Mg++, Fe++, Ca++, Zn++, Al+++
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Decreases bioavailability of ciprofloxacin
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oral contraceptives + antibiotics
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Decreases efficacy of oral contraceptives
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methotrexate + cotrimoxazole (Bactrim), NSAIDs, or ASA
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Increases methotrexate concentration
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oral contraceptives + smoking
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Increases CV risk (MI, stroke, thromboembolism) in pts older than 35
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warfarin + rifampin
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Decreases effectiveness of warfarin
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warfarin + cimetidine, cotrimoxazole, oxandrolone or amiodarone
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Increases risk of bleeding
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warfarin + asprin or NSAIDs
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Increases risk of bleeding
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furosemide + NSAIDs
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Decreases diuretic effects
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rifampin or St. Johns Wort + nelfinavir, indinavir or ritonavir
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Decreased protease inhibitor levels, probably decreased efficacy, and increased chance of resistance
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caffeine + ciprofloxacin
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Increased caffeine levels and effects
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clonidine + tricyclic antidepressents
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Inhibits antihypertensive response to clonidine
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imipramine + epinephrine
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Excessive increase in blood pressure
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allopurinol + azathioprine (6-mercaptopurine)
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Increases toxicity of azathioprine (increased bioavailability)
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itraconazole or gemfibrozil + simvastatin or lovastatin
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Reduced metabolism of the statins, increased myopathy
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cholestyramine or colestipol + pravastatin or fluvastatin
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Reduced absorption of the statins
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MAO inhibitors + SSRIs (fluoxetine)
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Serotonin syndrome
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MAO inhibitors + pseudoephedrine
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Severe hypertension
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potassium + ace inhibitors (captopril) or spironolactone
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Increases potassium levels
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thyroid hormone + Ca++ or raloxifen
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Reduced absorption of thyroid hormone
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lithium + sodium chloride
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Lithium levels change inversely proportionally to sodium levels
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