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36 Cards in this Set
- Front
- Back
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Which part of the GI tract has the highest concentration of enzymes?
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upper small intestine (duodenum and jejunum)
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What property of antacids allows them to decrease the effectiveness and absorption of some drugs?
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polyvalent cations chelate with drug molecules (Calcium, aluminum, magnesium
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List some drugs that interact with antacids:
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atenolol
ciprofloxacin enoxacin isoniazid ketoconazole norfloxacin ofloxacin tetracycline |
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What is the single most abundant enzyme in the gut?
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CYP3A4
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Are protein binding interactions relevant? Why or why not?
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Absolutely not. Good question.
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What are the seven enzymes that are responsible for the majority of drug metabolism?
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CYP1A2
CYP2C8 CYP2C9 CYP2C19 CYP2D6 CYP2E1 CYP3A4 |
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List 4 broad spectrum inducers and which enzymes they induce:
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Carbamazepine, Phenytoin, Phenobarbital, Rifampin
CYP1A2, CYP2C, CYP3A, UGT |
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What effect does smoking have on an enzyme, and which enzyme does it affect?
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Smoking (burning hydrocarbons) induces CYP1A2
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What effect does alcohol have on an enzyme, and which enzyme does it affect?
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Alcohol induces CYP2E1
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Besides four broad spectrum inducers, list six other other drugs that induce CYP3A:
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Felbamate
Topiramate Oxcarbazepine Griseofulvin Nevirapine St. John's Wort |
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
fluvoxamine |
inhibit CYP1A2
inhibit CYP2C19 |
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
fluconazole |
inhibit CYP2C9
inhibit CYP3A4 |
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
amiodarone |
inhibit CYP2C9
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
cimetidine |
inhibit CYP2C9
inhibit CYP3A4 |
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
propoxyphene |
inhibit CYP2C9
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
valproate |
inhibit CYP2C9
inhibit UGTs |
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
miconazole |
inhibit CYP2C9
inhibit CYP3A4 |
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
felbamate |
inhibit CYP2C19
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
fluoxetine |
inhibit CYP2C19
inhibit CYP2D6 (same as norfluoxetine) |
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
isoniazid |
inhibit CYP2C19
inhibit CYP3A4 |
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
oxcarbazepine |
inhibit CYP2C19
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
ticlopidine |
inhibit CYP2C19
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
topiramate |
inhibit CYP2C19
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
quindine |
inhibit CYP2D6
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
paroxetine |
inhibit CYP2D6
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
ritonavir |
inhibit CYP2D6
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
chloraquine |
inhibit CYP2D6
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
diphenhydramine |
inhibit CYP2D6
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
erythromycin |
inhibit CYP3A4
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
clarithromycin |
inhibit CYP3A4
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
diltiazem |
inhibit CYP3A4
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
grapefruit juice |
inhibit CYP3A4
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
itraconazole |
inhibit CYP3A4
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
ketoconazole |
inhibit CYP3A4
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
troleandomycin |
inhibit CYP3A4
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Which enzyme does the following drug induce or inhibit, and does it induce or inhibit?
verapamil |
inhibit CYP3A4
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