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10 Cards in this Set
- Front
- Back
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Drug interactions can be beneficial or adverse, T or F? |
True |
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What types of interactions are possible besides drug-drug? |
Drug-food Drug-disease |
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What are the 4 components of Pharmacokinetics? |
Absorption Distribution Metabolism Excretion |
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Absorption components |
Presence of absence of food Formation of complexes pH changes GI emptying and motility Induction or inhibition of P-glycoprotein |
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Distribution components |
Displacement from protein binding Metabolism - CP450 induction or inhibition |
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Metabolism components |
CP450 induction/Inhibition |
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Excretion components |
Change in GFR Competition for common tubular support system e.g. NSAIDS reduce renal excretion of methotrexate |
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Drug with narrow therapeutic range mnemonic |
W I L D C A T |
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Pharmacodynamic interactions definition |
No change in the amount of the drug in the body but change in the pharmacological effect |
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Pharmacodynamic interactions components |
Interactions at receptors Similar side effect profile Actions on same site or physiological system |
