Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
18 Cards in this Set
- Front
- Back
|
pharmacodynamic
|
sildenafil and nitroglycerin: sildenafil inhibits breakdown of cyclic gmp and nitroglycerin increases production
|
|
|
pharmacokinetic
|
alterations in absorption, distribution, metab or excretion
|
|
|
cholestyramine and levothyroxine
|
dec levo absorp
|
|
|
antacid (ca al mg) and tetracyc
|
dec tet absorption
|
|
|
ferrous sulfate and tetracyc
|
dec tetracyc absorption
|
|
|
altered ph of gastrointes fluid
|
cimetidine and ketocon--dec ketoconazole absorption by increasing gastric ph
|
|
|
inducer of p 450's
|
phenobarbital, carbamazepine, phenytoin, rifampin, st john wort
|
|
|
inc renal excretion how
|
alkanize urine of weak acid
or acidify for weak base |
|
|
p450 inhib
|
amiodarone, grapefruit juice, ketoconazole,
|
|
|
ketoconazole and...
|
terfenidine
|
|
|
amiodarone and....
|
warfarin
|
|
|
ketoconazole and terfenidine can cause?
|
torsade de pointe
|
|
|
antimetabolite of terfinadine
|
fexofenadine
|
|
|
grapefruit juice and ....
|
inc levels of felodopine (calcium channel blocker)
|
|
|
inhibition of monoamine oxidase
|
tyramine can release catecholamines but normally mao breaks down tyramine
but if inhib then can inc blood pressure also, mao inhib + serotonin reuptake inhib (prozac) can lead to serotonin syndrome |
|
|
dec urinary excretion
|
probenecid and penicillin, dec pen excretion
|
|
|
another
|
thiazide diuretic and lithium dec lith excretion
|
|
|
inhib of p glycoprotein mediated transport
|
quinidine and digoxin, inc plasma digoxin concentration
|
