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11 Cards in this Set
- Front
- Back
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What are the 3 main sources pertaining to pregnancy and lactation?
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Weiner, Briggs and Reprorisk (part of micromedex)
Weiner more extensive than Briggs |
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What are the 5 categories of FDA risk?
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A: controlled studies in women do not demonstrate risk to fetus in 1st trimester (no evidence in 2nd/3rd)
B: animal studies either show no risk or show AE not confirmed by controlled studies C: animal studies show risk to fetus and there are no controlled trials in women Give drug only if benefit>risk D: Positive evidence of human fetal risk. Benefits may still outweigh risk X: Evidence of risk in animals, human beings or both Risk > Benefit |
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What are the 5 Dr. Hale's Lactation Risk Categories?
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L1: Safest. No risk or product is not orally available for infants
L2: Studies are limited but show no AE to fetus L3: No controlled studies done or studies show minimal non-threatening AE's L4: Positive evidence of risk L5: Studies show significant risk Risk > Benefit |
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What is the LactMed Database?
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A database with TOXNET(Toxicology Network)
Provides info on drug levels, effects on infants and lactation, AAP and alternatives. |
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What are 5 drug characteristics that determine transfer into human milk?
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Degree of protein binding
Concentrations in maternal plasma Molecular Weight Lipophilicity Half-life |
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Who are more at risk, younger or older infants?
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Younger
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What should be avoided during pregnancy?
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High dose vitamins, unusual supplements or any unnecessary medication
It is also important to choose medications that are well published instead of newer medications. If relative infant dose is less than 10%, then they are safe to use. |
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What type of information is included in NeoFax?
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Dose and Administration
Uses AE's Pharmacology |
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What levels of development are covered in "The Teddy Bear Book"?
What information is included? |
Neonates through Adolescents
Dose Adjustments for organ dysfunction Maximum dose IV Push Maximum concentration Intermittent Infusion |
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What book would you consult for instructions on Oral or liquid suspensions for youth's?
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Pediatric Drug Formulations
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What are 3 considerations for Pediatric Pharmacy?
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Drugs may be marked for use in children without extensive study
Pediatric dosage forms may not be commercially available Dosages must be individualized by age, weight and body surface area |
